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. 1991 Jun;65(6):3359–3364. doi: 10.1128/jvi.65.6.3359-3364.1991

Feline immunodeficiency virus infects both CD4+ and CD8+ T lymphocytes.

W C Brown 1, L Bissey 1, K S Logan 1, N C Pedersen 1, J H Elder 1, E W Collisson 1
PMCID: PMC240997  PMID: 1709703

Abstract

Monoclonal populations of feline T cells, derived from a specific-pathogen-free cat and expressing either the CD4 or CD8 surface antigen, were infected in vitro with two geographically distinct isolates of feline immunodeficiency virus (FIV). Both infected T-cell subsets exhibited decreased cell viability, expressed FIV-encoded proteins, and generated reverse transcriptase activity. All clones examined retained their original surface phenotype after infection. It appears, therefore, that both CD4+ and CD8+ T cells may be productively infected by FIV in vivo.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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