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. 1991 Jun;65(6):3365–3368. doi: 10.1128/jvi.65.6.3365-3368.1991

Pseudorabies virus-induced suppression of major histocompatibility complex class I antigen expression.

M W Mellencamp 1, P C O'Brien 1, J R Stevenson 1
PMCID: PMC240998  PMID: 1851884

Abstract

The ability of pseudorabies virus (PrV) to down-modulate expression of major histocompatibility complex class I antigens in murine and porcine cells was investigated. When quantified by flow cytometry, surface expression of class I Kk and Dk antigens on PrV-infected cells decreased by 60% or more. Down-modulation was associated with a decrease in total cellular class I antigens, indicating regulation at the transcriptional or posttranscriptional level. PrV did not suppress expression of transferrin receptor, suggesting a selective regulatory mechanism.

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Selected References

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