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. 1992 Jun;66(6):3677–3682. doi: 10.1128/jvi.66.6.3677-3682.1992

A second envelope glycoprotein mediates neutralization of a pestivirus, hog cholera virus.

E Weiland 1, R Ahl 1, R Stark 1, F Weiland 1, H J Thiel 1
PMCID: PMC241151  PMID: 1583727

Abstract

Several monoclonal antibodies (MAbs) raised against hog cholera virus (HCV) reacted with the HCV structural glycoprotein gp44/48 and neutralized the virus. The presence of HCV gp44/48 on the viral surface was directly demonstrated by immunogold electron microscopy. Eight anti-HCV gp44/48 MAbs were tested by immunoperoxidase assay against a panel of pestivirus strains. Each MAb showed a distinct pattern of reactivity with HCV strains. It is suggested that the MAbs are well suited for epidemiological investigations of HCV outbreaks.

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Selected References

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