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. 1992 Jun;66(6):3950–3954. doi: 10.1128/jvi.66.6.3950-3954.1992

Protein of macaques against infection with simian type D retrovirus (SRV-1) by immunization with recombinant vaccinia virus expressing the envelope glycoproteins of either SRV-1 or Mason-Pfizer monkey virus (SRV-3).

B A Brody 1, E Hunter 1, J D Kluge 1, R Lasarow 1, M Gardner 1, P A Marx 1
PMCID: PMC241188  PMID: 1316495

Abstract

Rhesus macaques were immunized with live vaccinia virus recombinants expressing the envelope glycoproteins (gp70 and gp22) of simian type D retrovirus (SRV), serotype 1 or 3. All of the animals immunized with either the SRV-1 env or the SRV-3 env vaccinia virus recombinant developed neutralizing antibodies against the homologous SRV. In addition, both groups developed cross-reactive antibodies and were protected against an intravenous live-virus challenge with SRV-1. The four control animals immunized with a vaccinia virus recombinant expressing the G protein of respiratory syncytial virus were not protected against the same SRV-1 challenge. Although SRV-1 and SRV-3 immune sera showed cross-neutralization, they failed to neutralize a separate, more distantly related serotype, SRV-2, in an in vitro assay. These findings are consistent with the known degree of serologic and genetic relatedness of these three SRV strains.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ball L. A., Young K. K., Anderson K., Collins P. L., Wertz G. W. Expression of the major glycoprotein G of human respiratory syncytial virus from recombinant vaccinia virus vectors. Proc Natl Acad Sci U S A. 1986 Jan;83(2):246–250. doi: 10.1073/pnas.83.2.246. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Brody B. A., Hunter E. Mutations within the env gene of Mason-Pfizer monkey virus: effects on protein transport and SU-TM association. J Virol. 1992 Jun;66(6):3466–3475. doi: 10.1128/jvi.66.6.3466-3475.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bryant M. L., Gardner M. B., Marx P. A., Maul D. H., Lerche N. W., Osborn K. G., Lowenstine L. J., Bodgen A., Arthur L. O., Hunter E. Immunodeficiency in rhesus monkeys associated with the original Mason-Pfizer monkey virus. J Natl Cancer Inst. 1986 Oct;77(4):957–965. [PubMed] [Google Scholar]
  4. Chakrabarti S., Brechling K., Moss B. Vaccinia virus expression vector: coexpression of beta-galactosidase provides visual screening of recombinant virus plaques. Mol Cell Biol. 1985 Dec;5(12):3403–3409. doi: 10.1128/mcb.5.12.3403. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Daniel M. D., Letvin N. L., King N. W., Kannagi M., Sehgal P. K., Hunt R. D., Kanki P. J., Essex M., Desrosiers R. C. Isolation of T-cell tropic HTLV-III-like retrovirus from macaques. Science. 1985 Jun 7;228(4704):1201–1204. doi: 10.1126/science.3159089. [DOI] [PubMed] [Google Scholar]
  6. Fine D. L., Landon J. C., Pienta R. J., Kubicek M. T., Valerio M. G., Loeb W. F., Chopra H. C. Responses of infant rhesus monkeys to inoculation with Mason-Pfizer monkey virus materials. J Natl Cancer Inst. 1975 Mar;54(3):651–658. [PubMed] [Google Scholar]
  7. Gardner M. B., Luciw P., Lerche N., Marx P. Nonhuman primate retrovirus isolates and AIDS. Adv Vet Sci Comp Med. 1988;32:171–226. doi: 10.1016/b978-0-12-039232-2.50011-6. [DOI] [PubMed] [Google Scholar]
  8. Heidecker G., Lerche N. W., Lowenstine L. J., Lackner A. A., Osborn K. G., Gardner M. B., Marx P. A. Induction of simian acquired immune deficiency syndrome (SAIDS) with a molecular clone of a type D SAIDS retrovirus. J Virol. 1987 Oct;61(10):3066–3071. doi: 10.1128/jvi.61.10.3066-3071.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Hruby D. E., Guarino L. A., Kates J. R. Vaccinia virus replication. I. Requirement for the host-cell nucleus. J Virol. 1979 Feb;29(2):705–715. doi: 10.1128/jvi.29.2.705-715.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Hu S. L., Zarling J. M., Chinn J., Travis B. M., Moran P. A., Sias J., Kuller L., Morton W. R., Heidecker G., Benveniste R. E. Protection of macaques against simian AIDS by immunization with a recombinant vaccinia virus expressing the envelope glycoproteins of simian type D retrovirus. Proc Natl Acad Sci U S A. 1989 Sep;86(18):7213–7217. doi: 10.1073/pnas.86.18.7213. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Jensen E. M., Zelljadt I., Chopra H. C., Mason M. M. Isolation and propagation of a virus from a spontaneous mammary carcinoma of a rhesus monkey. Cancer Res. 1970 Sep;30(9):2388–2393. [PubMed] [Google Scholar]
  12. Kwang H. S., Barr P. J., Sabin E. A., Sujipto S., Marx P. A., Power M. D., Bathurst I. C., Pedersen N. C. Simian retrovirus-D serotype 1 (SRV-1) envelope glycoproteins gp70 and gp20: expression in yeast cells and identification of specific antibodies in sera from monkeys that recovered from SRV-1 infection. J Virol. 1988 May;62(5):1774–1780. doi: 10.1128/jvi.62.5.1774-1780.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Kwang H. S., Pedersen N. C., Lerche N. W., Osborn K. G., Marx P. A., Gardner M. B. Viremia, antigenemia, and serum antibodies in rhesus macaques infected with simian retrovirus type 1 and their relationship to disease course. Lab Invest. 1987 Jun;56(6):591–597. [PubMed] [Google Scholar]
  14. Lerche N. W., Marx P. A., Gardner M. B. Elimination of type D retrovirus infection from group-housed rhesus monkeys using serial testing and removal. Lab Anim Sci. 1991 Apr;41(2):123–127. [PubMed] [Google Scholar]
  15. Lerche N. W., Osborn K. G., Marx P. A., Prahalada S., Maul D. H., Lowenstine L. J., Munn R. J., Bryant M. L., Henrickson R. V., Arthur L. O. Inapparent carriers of simian acquired immune deficiency syndrome type D retrovirus and disease transmission with saliva. J Natl Cancer Inst. 1986 Aug;77(2):489–496. [PubMed] [Google Scholar]
  16. Mackett M., Smith G. L., Moss B. General method for production and selection of infectious vaccinia virus recombinants expressing foreign genes. J Virol. 1984 Mar;49(3):857–864. doi: 10.1128/jvi.49.3.857-864.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Mackett M., Smith G. L., Moss B. Vaccinia virus: a selectable eukaryotic cloning and expression vector. Proc Natl Acad Sci U S A. 1982 Dec;79(23):7415–7419. doi: 10.1073/pnas.79.23.7415. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Mackett M., Smith G. L. Vaccinia virus expression vectors. J Gen Virol. 1986 Oct;67(Pt 10):2067–2082. doi: 10.1099/0022-1317-67-10-2067. [DOI] [PubMed] [Google Scholar]
  19. Marx P. A., Bryant M. L., Osborn K. G., Maul D. H., Lerche N. W., Lowenstine L. J., Kluge J. D., Zaiss C. P., Henrickson R. V., Shiigi S. M. Isolation of a new serotype of simian acquired immune deficiency syndrome type D retrovirus from Celebes black macaques (Macaca nigra) with immune deficiency and retroperitoneal fibromatosis. J Virol. 1985 Nov;56(2):571–578. doi: 10.1128/jvi.56.2.571-578.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Marx P. A., Maul D. H., Osborn K. G., Lerche N. W., Moody P., Lowenstine L. J., Henrickson R. V., Arthur L. O., Gilden R. V., Gravell M. Simian AIDS: isolation of a type D retrovirus and transmission of the disease. Science. 1984 Mar 9;223(4640):1083–1086. doi: 10.1126/science.6695196. [DOI] [PubMed] [Google Scholar]
  21. Marx P. A., Pedersen N. C., Lerche N. W., Osborn K. G., Lowenstine L. J., Lackner A. A., Maul D. H., Kwang H. S., Kluge J. D., Zaiss C. P. Prevention of simian acquired immune deficiency syndrome with a formalin-inactivated type D retrovirus vaccine. J Virol. 1986 Nov;60(2):431–435. doi: 10.1128/jvi.60.2.431-435.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Power M. D., Marx P. A., Bryant M. L., Gardner M. B., Barr P. J., Luciw P. A. Nucleotide sequence of SRV-1, a type D simian acquired immune deficiency syndrome retrovirus. Science. 1986 Mar 28;231(4745):1567–1572. doi: 10.1126/science.3006247. [DOI] [PubMed] [Google Scholar]
  23. Rhee S. S., Hui H. X., Hunter E. Preassembled capsids of type D retroviruses contain a signal sufficient for targeting specifically to the plasma membrane. J Virol. 1990 Aug;64(8):3844–3852. doi: 10.1128/jvi.64.8.3844-3852.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Sommerfelt M. A., Williams B. P., McKnight A., Goodfellow P. N., Weiss R. A. Localization of the receptor gene for type D simian retroviruses on human chromosome 19. J Virol. 1990 Dec;64(12):6214–6220. doi: 10.1128/jvi.64.12.6214-6220.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Sonigo P., Barker C., Hunter E., Wain-Hobson S. Nucleotide sequence of Mason-Pfizer monkey virus: an immunosuppressive D-type retrovirus. Cell. 1986 May 9;45(3):375–385. doi: 10.1016/0092-8674(86)90323-5. [DOI] [PubMed] [Google Scholar]
  26. Stromberg K., Benveniste R. E., Arthur L. O., Rabin H., Giddens W. E., Jr, Ochs H. D., Morton W. R., Tsai C. C. Characterization of exogenous type D retrovirus from a fibroma of a macaque with simian AIDS and fibromatosis. Science. 1984 Apr 20;224(4646):289–282. doi: 10.1126/science.6200929. [DOI] [PubMed] [Google Scholar]
  27. Thayer R. M., Power M. D., Bryant M. L., Gardner M. B., Barr P. J., Luciw P. A. Sequence relationships of type D retroviruses which cause simian acquired immunodeficiency syndrome. Virology. 1987 Apr;157(2):317–329. doi: 10.1016/0042-6822(87)90274-1. [DOI] [PubMed] [Google Scholar]
  28. Zoller M. J., Smith M. Oligonucleotide-directed mutagenesis of DNA fragments cloned into M13 vectors. Methods Enzymol. 1983;100:468–500. doi: 10.1016/0076-6879(83)00074-9. [DOI] [PubMed] [Google Scholar]

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