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. 1992 Jun;66(6):3961–3965. doi: 10.1128/jvi.66.6.3961-3965.1992

Activation of the human immunodeficiency virus type 1 enhancer is not dependent on NFAT-1.

D M Markovitz 1, M C Hannibal 1, M J Smith 1, R Cossman 1, G J Nabel 1
PMCID: PMC241190  PMID: 1533884

Abstract

The function of a putative NFAT-1 site in the human immunodeficiency virus type 1 enhancer has been analyzed. Activation by the T-cell antigen receptor is minimal in Jurkat cells and is mediated by the kappa B sites. The putative NFAT-1 region is not required for the response to anti-CD3 or to mitogens in T-cell, B-cell, or monocyte/macrophage leukemia lines, nor is it a cis-acting negative regulatory element.

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Selected References

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