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. 1992 Jun;66(6):3966–3970. doi: 10.1128/jvi.66.6.3966-3970.1992

Differential human immunodeficiency virus expression in CD4+ cloned lymphocytes: from viral latency to replication.

A Chapel 1, A Bensussan 1, E Vilmer 1, D Dormont 1
PMCID: PMC241191  PMID: 1374814

Abstract

By using cloning methodology, 13 CD4+, CD8-, CD45RO+, and CD29+ clones, isolated from human immunodeficiency virus (HIV)-negative donors, have been characterized and tested regarding their susceptibility to two strains of HIV type 1 (HIV-1). Infected clones possess integrated provirus. Only six are able to replicate HIV-1, while seven may normally grow without cytopathic effect and without viral replication. These results argue that all CD4+ lymphocyte clones may be infectable but that a heterogeneity exists regarding their abilities to replicate HIV-1.

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Selected References

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