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. 1992 Jul;66(7):4587–4590. doi: 10.1128/jvi.66.7.4587-4590.1992

Infection by polyomavirus of murine cells deficient in class I major histocompatibility complex expression.

N Sanjuan 1, M Zijlstra 1, J Carroll 1, R Jaenisch 1, T Benjamin 1
PMCID: PMC241273  PMID: 1318421

Abstract

Embryonic fibroblasts and kidney epithelial cells from beta 2-microglobulin-deficient mice were as infectible by polyomavirus as cells from normal littermates were, as judged by expression of nuclear viral capsid antigen, development of cytopathic effects, and yields of infectious virus. We conclude that expression of intact class I major histocompatibility complex molecules is not essential for polyomavirus infection.

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Selected References

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