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. 1992 Jul;66(7):4601–4605. doi: 10.1128/jvi.66.7.4601-4605.1992

Lymphocyte-facilitated infection of epithelia by human T-cell lymphotropic virus type I.

V R Zacharopoulos 1, M E Perotti 1, D M Phillips 1
PMCID: PMC241276  PMID: 1602562

Abstract

After the addition of human T-cell lymphotropic virus type I (HTLV-I)-infected lymphocytes to enterocyte monolayers, the lymphocytes adhered via microvilli from both cell types and shed virus onto the enterocyte surface. Virus fused with the epithelial membrane and infected these cells as confirmed by electron microscopic immunocytochemistry, in situ hybridization, and amplification by polymerase chain reaction.

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Selected References

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  1. Ando Y., Kakimoto K., Tanigawa T., Furuki K., Saito K., Nakano S., Hashimoto H., Moriyama I., Ichijo M., Toyama T. Effect of freeze-thawing breast milk on vertical HTLV-I transmission from seropositive mothers to children. Jpn J Cancer Res. 1989 May;80(5):405–407. doi: 10.1111/j.1349-7006.1989.tb02327.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Carlemalm E., Villiger W., Hobot J. A., Acetarin J. D., Kellenberger E. Low temperature embedding with Lowicryl resins: two new formulations and some applications. J Microsc. 1985 Oct;140(Pt 1):55–63. doi: 10.1111/j.1365-2818.1985.tb02660.x. [DOI] [PubMed] [Google Scholar]
  3. Chen I. S., Quan S. G., Golde D. W. Human T-cell leukemia virus type II transforms normal human lymphocytes. Proc Natl Acad Sci U S A. 1983 Nov;80(22):7006–7009. doi: 10.1073/pnas.80.22.7006. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Fantini J., Baghdiguian S., Yahi N., Chermann J. C. Selected human immunodeficiency virus replicates preferentially through the basolateral surface of differentiated human colon epithelial cells. Virology. 1991 Dec;185(2):904–907. doi: 10.1016/0042-6822(91)90570-2. [DOI] [PubMed] [Google Scholar]
  5. Hino S., Yamaguchi K., Katamine S., Sugiyama H., Amagasaki T., Kinoshita K., Yoshida Y., Doi H., Tsuji Y., Miyamoto T. Mother-to-child transmission of human T-cell leukemia virus type-I. Jpn J Cancer Res. 1985 Jun;76(6):474–480. [PubMed] [Google Scholar]
  6. Hjelle B. Human T-cell leukemia/lymphoma viruses. Life cycle, pathogenicity, epidemiology, and diagnosis. Arch Pathol Lab Med. 1991 May;115(5):440–450. [PubMed] [Google Scholar]
  7. Hoxie J. A., Matthews D. M., Cines D. B. Infection of human endothelial cells by human T-cell leukemia virus type I. Proc Natl Acad Sci U S A. 1984 Dec;81(23):7591–7595. doi: 10.1073/pnas.81.23.7591. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Kinoshita K., Yamanouchi K., Ikeda S., Momita S., Amagasaki T., Soda H., Ichimaru M., Moriuchi R., Katamine S., Miyamoto T. Oral infection of a common marmoset with human T-cell leukemia virus type-I (HTLV-I) by inoculating fresh human milk of HTLV-I carrier mothers. Jpn J Cancer Res. 1985 Dec;76(12):1147–1153. [PubMed] [Google Scholar]
  9. Nakano S., Ando Y., Ichijo M., Moriyama I., Saito S., Sugamura K., Hinuma Y. Search for possible routes of vertical and horizontal transmission of adult T-cell leukemia virus. Gan. 1984 Dec;75(12):1044–1045. [PubMed] [Google Scholar]
  10. Owens R. J., Dubay J. W., Hunter E., Compans R. W. Human immunodeficiency virus envelope protein determines the site of virus release in polarized epithelial cells. Proc Natl Acad Sci U S A. 1991 May 1;88(9):3987–3991. doi: 10.1073/pnas.88.9.3987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Phillips D. M., Bourinbaiar A. S. Mechanism of HIV spread from lymphocytes to epithelia. Virology. 1992 Jan;186(1):261–273. doi: 10.1016/0042-6822(92)90080-9. [DOI] [PubMed] [Google Scholar]
  12. Ruscetti F. W., Robert-Guroff M., Ceccherini-Nelli L., Minowada J., Popovic M., Gallo R. C. Persistent in vitro infection by human T-cell leukemia-lymphoma virus (HTLV) of normal human T-lymphocytes from blood relatives of patients with HTLV-associated mature T-cell neoplasms. Int J Cancer. 1983 Feb 15;31(2):171–180. doi: 10.1002/ijc.2910310207. [DOI] [PubMed] [Google Scholar]
  13. Singer R. H., Byron K. S., Lawrence J. B., Sullivan J. L. Detection of HIV-1-infected cells from patients using nonisotopic in situ hybridization. Blood. 1989 Nov 1;74(6):2295–2301. [PubMed] [Google Scholar]
  14. Uemura Y., Kotani S., Yoshimoto S., Fujishita M., Yano S., Ohtsuki Y., Miyoshi I. Oral transmission of human T-cell leukemia virus type I in the rabbit. Jpn J Cancer Res. 1986 Oct;77(10):970–973. [PubMed] [Google Scholar]
  15. Yamamoto Y., Gunsalus G. L., Sundaram K., Thau R. B. Characterization of anti oLH beta-antibodies acting as contraceptives in rhesus monkeys. I. In vitro binding properties. J Reprod Immunol. 1982 Sep;4(5):295–311. doi: 10.1016/0165-0378(82)90004-3. [DOI] [PubMed] [Google Scholar]
  16. Yamanouchi K., Kinoshita K., Moriuchi R., Katamine S., Amagasaki T., Ikeda S., Ichimaru M., Miyamoto T., Hino S. Oral transmission of human T-cell leukemia virus type-I into a common marmoset (Callithrix jacchus) as an experimental model for milk-borne transmission. Jpn J Cancer Res. 1985 Jun;76(6):481–487. [PubMed] [Google Scholar]
  17. de Rossi A., Aldovini A., Franchini G., Mann D., Gallo R. C., Wong-Staal F. Clonal selection of T lymphocytes infected by cell-free human T-cell leukemia/lymphoma virus type I: parameters of virus integration and expression. Virology. 1985 Jun;143(2):640–645. doi: 10.1016/0042-6822(85)90405-2. [DOI] [PubMed] [Google Scholar]

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