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. 1992 Aug;66(8):5152–5156. doi: 10.1128/jvi.66.8.5152-5156.1992

Postinfection treatment with antiviral serum results in survival of neural cells productively infected with virulent poliovirus.

E A Tolskaya 1, T A Ivannikova 1, M S Kolesnikova 1, S G Drozdov 1, V I Agol 1
PMCID: PMC241394  PMID: 1321295

Abstract

The death of human neuroblastoma cells undergoing productive infection with virulent poliovirus was prevented by addition of antiserum against the virus a few hours after the onset of infection; this treatment, however, did not prevent reproduction of the virus. Despite the presence of the viral antigen, the cells retained the ability to divide. Upon further cultivation in the absence of antiserum, the cells developed specific postinfection immunity or resistance to superinfection with poliovirus.

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Selected References

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  1. Agol V. I., Drozdov S. G., Ivannikova T. A., Kolesnikova M. S., Korolev M. B., Tolskaya E. A. Restricted growth of attenuated poliovirus strains in cultured cells of a human neuroblastoma. J Virol. 1989 Sep;63(9):4034–4038. doi: 10.1128/jvi.63.9.4034-4038.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Colbère-Garapin F., Christodoulou C., Crainic R., Pelletier I. Persistent poliovirus infection of human neuroblastoma cells. Proc Natl Acad Sci U S A. 1989 Oct;86(19):7590–7594. doi: 10.1073/pnas.86.19.7590. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Fujinami R. S., Oldstone M. B. Antiviral antibody reacting on the plasma membrane alters measles virus expression inside the cell. Nature. 1979 Jun 7;279(5713):529–530. doi: 10.1038/279529a0. [DOI] [PubMed] [Google Scholar]
  4. Fujinami R. S., Rosenthal A., Lampert P. W., Zurbriggen A., Yamada M. Survival of athymic (nu/nu) mice after Theiler's murine encephalomyelitis virus infection by passive administration of neutralizing monoclonal antibody. J Virol. 1989 May;63(5):2081–2087. doi: 10.1128/jvi.63.5.2081-2087.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. La Monica N., Racaniello V. R. Differences in replication of attenuated and neurovirulent polioviruses in human neuroblastoma cell line SH-SY5Y. J Virol. 1989 May;63(5):2357–2360. doi: 10.1128/jvi.63.5.2357-2360.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Levine B., Hardwick J. M., Trapp B. D., Crawford T. O., Bollinger R. C., Griffin D. E. Antibody-mediated clearance of alphavirus infection from neurons. Science. 1991 Nov 8;254(5033):856–860. doi: 10.1126/science.1658936. [DOI] [PubMed] [Google Scholar]
  7. Minor P. D., Ferguson M., Evans D. M., Almond J. W., Icenogle J. P. Antigenic structure of polioviruses of serotypes 1, 2 and 3. J Gen Virol. 1986 Jul;67(Pt 7):1283–1291. doi: 10.1099/0022-1317-67-7-1283. [DOI] [PubMed] [Google Scholar]
  8. Minor P. D., Ferguson M., Katrak K., Wood D., John A., Howlett J., Dunn G., Burke K., Almond J. W. Antigenic structure of chimeras of type 1 and type 3 polioviruses involving antigenic sites 2, 3 and 4. J Gen Virol. 1991 Oct;72(Pt 10):2475–2481. doi: 10.1099/0022-1317-72-10-2475. [DOI] [PubMed] [Google Scholar]
  9. Oakes J. E., Lausch R. N. Monoclonal antibodies suppress replication of herpes simplex virus type 1 in trigeminal ganglia. J Virol. 1984 Sep;51(3):656–661. doi: 10.1128/jvi.51.3.656-661.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Romanova L. I., Tolskaya E. A., Agol V. I. Antigenic and structural relatedness among non-capsid and capsid polypeptides of polioviruses belonging to different serotypes. J Gen Virol. 1981 Feb;52(Pt 2):279–289. doi: 10.1099/0022-1317-52-2-279. [DOI] [PubMed] [Google Scholar]
  11. Shariff D. M., Davies J., Desperbasques M., Billstrom M., Geerligs H. J., Welling G. W., Welling-Wester S., Buchan A., Skinner G. R. Immune inhibition of virus release from human and nonhuman cells by antibody to viral and host cell determinants. Intervirology. 1991;32(1):28–36. doi: 10.1159/000150182. [DOI] [PubMed] [Google Scholar]
  12. Tyler K. L., Virgin H. W., 4th, Bassel-Duby R., Fields B. N. Antibody inhibits defined stages in the pathogenesis of reovirus serotype 3 infection of the central nervous system. J Exp Med. 1989 Sep 1;170(3):887–900. doi: 10.1084/jem.170.3.887. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Virgin H. W., 4th, Bassel-Duby R., Fields B. N., Tyler K. L. Antibody protects against lethal infection with the neurally spreading reovirus type 3 (Dearing). J Virol. 1988 Dec;62(12):4594–4604. doi: 10.1128/jvi.62.12.4594-4604.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]

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