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. 1991 Jul;65(7):3891–3894. doi: 10.1128/jvi.65.7.3891-3894.1991

Equine H7N7 influenza A viruses are highly pathogenic in mice without adaptation: potential use as an animal model.

Y Kawaoka 1
PMCID: PMC241422  PMID: 2041098

Abstract

Equine H7N7 influenza A viruses, representing a broad range of isolates, were lethal in mice without adaptation. After repeated passages, A/Equine/London/1416/73 acquired neurotropism upon intranasal infection. Thus, mice infected with equine influenza A viruses provide a model system for the study of highly virulent mammalian influenza viruses.

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Selected References

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