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. 1991 Jul;65(7):3903–3905. doi: 10.1128/jvi.65.7.3903-3905.1991

Cap-binding complex protein p220 is not cleaved during echovirus 22 replication in HeLa cells.

B G Coller 1, S M Tracy 1, D Etchison 1
PMCID: PMC241425  PMID: 2041099

Abstract

Previously we demonstrated that echovirus 22 is an atypical enterovirus which does not shut off host cell protein synthesis. We extend these findings by showing that echovirus 22 does not cleave p220, part of the cellular cap-binding complex necessary for cap-dependent translation, suggesting a biology more consistent with cardioviruses than enteroviruses.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Auvinen P., Hyypiä T. Echoviruses include genetically distinct serotypes. J Gen Virol. 1990 Sep;71(Pt 9):2133–2139. doi: 10.1099/0022-1317-71-9-2133. [DOI] [PubMed] [Google Scholar]
  2. CROWTHER D., MELNICK J. L. Studies of the inhibitory action of guanidine on poliovirus multiplication in cell cultures. Virology. 1961 Sep;15:65–74. doi: 10.1016/0042-6822(61)90078-2. [DOI] [PubMed] [Google Scholar]
  3. Coller B. A., Chapman N. M., Beck M. A., Pallansch M. A., Gauntt C. J., Tracy S. M. Echovirus 22 is an atypical enterovirus. J Virol. 1990 Jun;64(6):2692–2701. doi: 10.1128/jvi.64.6.2692-2701.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Etchison D., Etchison J. R. Monoclonal antibody-aided characterization of cellular p220 in uninfected and poliovirus-infected HeLa cells: subcellular distribution and identification of conformers. J Virol. 1987 Sep;61(9):2702–2710. doi: 10.1128/jvi.61.9.2702-2710.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Etchison D., Milburn S. C., Edery I., Sonenberg N., Hershey J. W. Inhibition of HeLa cell protein synthesis following poliovirus infection correlates with the proteolysis of a 220,000-dalton polypeptide associated with eucaryotic initiation factor 3 and a cap binding protein complex. J Biol Chem. 1982 Dec 25;257(24):14806–14810. [PubMed] [Google Scholar]
  6. Figueroa J. P., Ashley D., King D., Hull B. An outbreak of acute flaccid paralysis in Jamaica associated with echovirus type 22. J Med Virol. 1989 Dec;29(4):315–319. doi: 10.1002/jmv.1890290418. [DOI] [PubMed] [Google Scholar]
  7. HOLLAND J. J. ENTEROVIRUS ENTRANCE INTO SPECIFIC HOST CELLS, AND SUBSEQUENT ALTERATIONS OF CELL PROTEIN AND NUCLEIC ACID SYNTHESIS. Bacteriol Rev. 1964 Mar;28:2–13. doi: 10.1128/br.28.1.2-13.1964. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Jamison R. M. An electron microscopic study of the intracellular development of echovirus 22. Arch Gesamte Virusforsch. 1974;44(3):184–194. doi: 10.1007/BF01240606. [DOI] [PubMed] [Google Scholar]
  9. Jen G., Thach R. E. Inhibition of host translation in encephalomyocarditis virus-infected L cells: a novel mechanism. J Virol. 1982 Jul;43(1):250–261. doi: 10.1128/jvi.43.1.250-261.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Koskiniemi M., Paetau R., Linnavuori K. Severe encephalitis associated with disseminated echovirus 22 infection. Scand J Infect Dis. 1989;21(4):463–466. doi: 10.3109/00365548909167453. [DOI] [PubMed] [Google Scholar]
  11. Kräusslich H. G., Nicklin M. J., Toyoda H., Etchison D., Wimmer E. Poliovirus proteinase 2A induces cleavage of eucaryotic initiation factor 4F polypeptide p220. J Virol. 1987 Sep;61(9):2711–2718. doi: 10.1128/jvi.61.9.2711-2718.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Kräusslich H. G., Wimmer E. Viral proteinases. Annu Rev Biochem. 1988;57:701–754. doi: 10.1146/annurev.bi.57.070188.003413. [DOI] [PubMed] [Google Scholar]
  13. Maller H. M., Powars D. F., Horowitz R. E., Portnoy B. Fatal myocarditis associated with ECHO virus, type 22, infection in a child with apparent immunological deficiency. J Pediatr. 1967 Aug;71(2):204–210. doi: 10.1016/s0022-3476(67)80073-8. [DOI] [PubMed] [Google Scholar]
  14. Rose J. K., Trachsel H., Leong K., Baltimore D. Inhibition of translation by poliovirus: inactivation of a specific initiation factor. Proc Natl Acad Sci U S A. 1978 Jun;75(6):2732–2736. doi: 10.1073/pnas.75.6.2732. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Seal L. A., Jamison R. M. A structural model for the genome of echovirus 22. Arch Virol. 1990;111(1-2):45–61. doi: 10.1007/BF01310504. [DOI] [PubMed] [Google Scholar]
  16. Seal L. A., Jamison R. M. Evidence for secondary structure within the virion RNA of echovirus 22. J Virol. 1984 May;50(2):641–644. doi: 10.1128/jvi.50.2.641-644.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. TAMM I., EGGERS H. J. Differences in the selective virus inhibitory action of 2-(alpha-hydroxybenzyl)-benzimidazole and guanidine HCl. Virology. 1962 Nov;18:439–447. doi: 10.1016/0042-6822(62)90034-x. [DOI] [PubMed] [Google Scholar]
  18. WIGAND R., SABIN A. B. Properties of ECHO types 22, 23 and 24 viruses. Arch Gesamte Virusforsch. 1961;11:224–247. doi: 10.1007/BF01241688. [DOI] [PubMed] [Google Scholar]
  19. von Zeipel G. Most echoviruses reach higher titers in RD than in GMK-AH 1 cells, regardless of their passage history. Arch Virol. 1980;63(2):143–146. doi: 10.1007/BF01320771. [DOI] [PubMed] [Google Scholar]

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