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Applied and Environmental Microbiology logoLink to Applied and Environmental Microbiology
. 1984 Aug;48(2):280–284. doi: 10.1128/aem.48.2.280-284.1984

Characterization of Bacillus subtilis DSM704 and its production of 1-deoxynojirimycin.

D C Stein, L K Kopec, R E Yasbin, F E Young
PMCID: PMC241503  PMID: 6237607

Abstract

A Bacillus subtilis strain, DSM704, was characterized by genetic means, and its production of a human intestinal sucrase inhibitor, 1-deoxynojirimycin, was described. Synthesis of this compound is detected concomitant with the detection of heat-resistant spores. The amount of 1-deoxynojirimycin produced is highly dependent on the carbon source, with growth on substrates metabolized via glycolysis giving the greatest amount of production (up to 1 mg/ml). 1-Deoxynojirimycin appears to be nonmetabolizable by the producing strain in that it cannot serve as a sole carbon or nitrogen source.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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