Abstract
A severely thyrotoxic patient was found to have hypocalcaemia and tetany, which cleared when she became euthyroid. Cessation of treatment with propranolol and propylthiouracil resulted in a recurrence of the thyrotoxicosis and the reappearance of hypocalcaemia. Reinstitution of treatment resulted in a second remission of the thyrotoxicosis and correction of the hypocalcaemia. It is suggested that in this patient, the thyrotoxicosis was the cause of hypocalcaemia. The various pathogenetic mechanisms are discussed.
Full text
PDF


Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Aub J. C., Bauer W., Heath C., Ropes M. STUDIES OF CALCIUM AND PHOSPHORUS METABOLISM: III. The Effects of the Thyroid Hormone and Thyroid Disease. J Clin Invest. 1929 Apr;7(1):97–137. doi: 10.1172/JCI100223. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Edelstein S., Charman M., Lawson D. E., Kodicek E. Competitive protein-binding assay for 25-hydroxycholecalciferol. Clin Sci Mol Med. 1974 Feb;46(2):231–240. doi: 10.1042/cs0460231. [DOI] [PubMed] [Google Scholar]
- Farnsworth A. E., Dobyns B. M. Hypercalcaemia and thyrotoxicosis. Med J Aust. 1974 Nov 23;2(21):782–784. doi: 10.5694/j.1326-5377.1974.tb71172.x. [DOI] [PubMed] [Google Scholar]
- Haldimann B., Kaptein E. M., Singer F. R., Nicoloff J. T., Massry S. G. Intestinal calcium absorption in patients with hyperthyroidism. J Clin Endocrinol Metab. 1980 Nov;51(5):995–997. doi: 10.1210/jcem-51-5-995. [DOI] [PubMed] [Google Scholar]
- Mundy G. R., Shapiro J. L., Bandelin J. G., Canalis E. M., Raisz L. G. Direct stimulation of bone resorption by thyroid hormones. J Clin Invest. 1976 Sep;58(3):529–534. doi: 10.1172/JCI108497. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rude R. K., Singer F. R. Magnesium deficiency and excess. Annu Rev Med. 1981;32:245–259. doi: 10.1146/annurev.me.32.020181.001333. [DOI] [PubMed] [Google Scholar]
- Shafer R. B., Gregory D. H. Calcium malabsorption in hyperthyroidism. Gastroenterology. 1972 Aug;63(2):235–239. [PubMed] [Google Scholar]
- Singhelakis P., Alevizaki C. C., Ikkos D. G. Intestinal calcium absorption in hyperthyroidism. Metabolism. 1974 Apr;23(4):311–321. doi: 10.1016/0026-0495(74)90049-3. [DOI] [PubMed] [Google Scholar]
- Velentzas C., Oreopoulos D. G., From G., Porret B., Rapopart A. Vitamin-D levels in thyrotoxicosis. Lancet. 1977 Feb 12;1(8007):370–371. doi: 10.1016/s0140-6736(77)91177-1. [DOI] [PubMed] [Google Scholar]