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. 1983 May;59(691):299–303. doi: 10.1136/pgmj.59.691.299

Bone disease after jejuno-ileal bypass for morbid obesity.

I T Gilmore, J B Eastwood, W R Ellis, V A Luck, S Fenton, A J O'Grady, E Harris, I M Murray-Lyon
PMCID: PMC2417423  PMID: 6878100

Abstract

Fifteen patients who had undergone a 14 inches X 4 inches jejuno-ileal bypass operation for obesity, 3 to 4 years earlier, were investigated by iliac bone biopsy, radiology and routine biochemistry, including 25-hydroxy-vitamin D and parathyroid hormone estimations. Two patients had histological osteomalacia which was mild in one. A further 9 patients had abnormal bone biopsies, there being an excess of trabecular bone surface covered by osteoid with a normal or reduced amount of calcification front. Six of these 9 showed an increase in trabecular resorption, although in none were there excessive numbers of osteoclasts. The likely explanation for these findings is that these 9 patients had early osteomalacia with mild hyperparathyroidism, making a total of 11 patients out of 15 with osteomalacia. Radiology and blood chemistry were poor predictors of histological bone disease.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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