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. 1983 Mar;59(689):135–141. doi: 10.1136/pgmj.59.689.135

Pathological aspects of endomyocardial fibrosis.

E G Olsen
PMCID: PMC2417465  PMID: 6844195

Abstract

The studies leading up to the unitarian concept suggesting that endomyocardial fibrosis, described in the tropics, and Löffler's endocarditis parietalis fibroplastica (Löffler's endomyocardial disease), described in the temperate zone, belong to the same disease spectrum are detailed. Evidence that the eosinophil is involved in the pathogenesis of endomyocardial diseases, irrespective of the geographical origin, is presented. The findings of a similar abnormality in these cells obtained from patients in the tropical and temperate zones are briefly mentioned. In view of the evidence it is proposed that endomyocardial disease, associated with abnormal eosinophils, hitherto classified under the restrictive type of cardiomyopathy, be removed from this classification and reclassified under 'specific heart muscle disease'.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bell J. A., Jenkins B. S., Webb-Peploe M. M. Clinical, haemodynamic, and angiographic findings in Löffler's eosinophilic endocarditis. Br Heart J. 1976 Jun;38(6):541–548. doi: 10.1136/hrt.38.6.541. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Brockington I. F., Olsen E. G., Goodwin J. F. Endomyocardial fibrosis in Europeans resident in tropical Africa. Lancet. 1967 Mar 18;1(7490):583–588. doi: 10.1016/s0140-6736(67)90440-0. [DOI] [PubMed] [Google Scholar]
  3. Connor D. H., Somers K., Hutt M. S., Manion W. C., D'Arbela P. G. Endomyocardial fibrosis in Uganda (Davies' disease). 1. An epidemiologic, clinical, and pathologic study. Am Heart J. 1967 Nov;74(5):687–709. doi: 10.1016/0002-8703(67)90509-1. [DOI] [PubMed] [Google Scholar]
  4. Connor D. H., Somers K., Hutt M. S., Manion W. C., D'Arbela P. G. Endomyocardial fibrosis in Uganda (Davies' disease). II. An epidemiologic, clinical, and pathologic study. Am Heart J. 1968 Jan;75(1):107–124. doi: 10.1016/0002-8703(68)90122-1. [DOI] [PubMed] [Google Scholar]
  5. DAVIES J. N., BALL J. D. The pathology of endomyocardial fibrosis in Uganda. Br Heart J. 1955 Jul;17(3):337–359. doi: 10.1136/hrt.17.3.337. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Davies J., Spry C. J., Vijayaraghavan G., De Souza J. A. A comparison of the clinical and cardiological features of endomyocardial disease in temperate and tropical regions. Postgrad Med J. 1983 Mar;59(689):179–185. doi: 10.1136/pgmj.59.689.179. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Goodwin J. F. Endomyocardial disease--clinical features. Postgrad Med J. 1983 Mar;59(689):154–156. doi: 10.1136/pgmj.59.689.154. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Hutt M. S. Epidemiology aspects of endomyocardial fibrosis. Postgrad Med J. 1983 Mar;59(689):142–146. doi: 10.1136/pgmj.59.689.142. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Ive F. A., Willis A. J., Ikeme A. C., Brockington I. F. Endomyocardial fibrosis and filariasis. Q J Med. 1967 Oct;36(144):495–516. [PubMed] [Google Scholar]
  10. KONNO S., SAKAKIBARA S. ENDO-MYOCARDIAL BIOPSY. Dis Chest. 1963 Oct;44:345–350. doi: 10.1378/chest.44.4.345. [DOI] [PubMed] [Google Scholar]
  11. Olsen E. G. Endomyocardial firbrosis and Löffler's endocarditis parietalis fibroplastica. Postgrad Med J. 1977 Sep;53(623):538–540. doi: 10.1136/pgmj.53.623.538. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Olsen E. G. The pathology of cardiomyopathies. A critical analysis. Am Heart J. 1979 Sep;98(3):385–392. doi: 10.1016/0002-8703(79)90052-8. [DOI] [PubMed] [Google Scholar]
  13. Parry E. H., Abrahams D. G. The natural history of endomyocardial fibrosis. Q J Med. 1965 Oct;34(136):383–408. [PubMed] [Google Scholar]
  14. Patel A. K., D'Arbela P. G., Somers K. Endomyocardial fibrosis and eosinophilia. Br Heart J. 1977 Mar;39(3):238–241. doi: 10.1136/hrt.39.3.238. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Richardson P. J. King's endomyocardial bioptome. Lancet. 1974 Apr;1(7859):660–661. doi: 10.1016/s0140-6736(74)93204-8. [DOI] [PubMed] [Google Scholar]
  16. Roberts W. C., Liegler D. G., Carbone P. P. Endomyocardial disease and eosinophilia. A clinical and pathologic spectrum. Am J Med. 1969 Jan;46(1):28–42. doi: 10.1016/0002-9343(69)90055-2. [DOI] [PubMed] [Google Scholar]
  17. Shaper A. G., Hutt M. S., Coles R. M. Necropsy study of endomyocardial fibrosis and rheumatic heart disease in Uganda 1950-1965. Br Heart J. 1968 May;30(3):391–401. doi: 10.1136/hrt.30.3.391. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Spry C. J., Tai P. C. Studies on blood eosinophils. II. Patients with Löffler's cardiomyopathy. Clin Exp Immunol. 1976 Jun;24(3):423–434. [PMC free article] [PubMed] [Google Scholar]
  19. WEISS-CARMINE S. Die endocarditis parietalis fibroplastica mit Bluteosinophilie (Löffler) und ihre Stellung im Rahmen der Parietalendokardfibrosen. Schweiz Med Wochenschr. 1957 Jun 29;87(26):890–898. [PubMed] [Google Scholar]

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