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. 1984 May;60(703):324–327. doi: 10.1136/pgmj.60.703.324

High serum thyroxine-binding globulin--an important cause of hyperthyroxinaemia.

B C Leahy, D Davies, I Laing, L Walton
PMCID: PMC2417873  PMID: 6429654

Abstract

Four patients are described who had a significant elevation of serum thyroxine-binding globulin (TBG). Review of these patients indicated that inappropriate therapy for thyrotoxicosis had been given in three cases. A study of our laboratory records revealed that significant TBG elevation was a relatively common phenomenon which occurred in approximately 0.45% of our hospital population. Patients with this abnormality have serum thyroxine levels which are comparable to those with clinical thyrotoxicosis. Tri-iodothyronine is frequently elevated though less so than in patients with clinical thyrotoxicosis. Measurement of TBG is indicated in all cases of hyperthyroxinaemia in which the clinical features of thyrotoxicosis are doubtful. The TRH test was found to be most useful in evaluating the thyroid status of these patients.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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