Abstract
Thirty patients with peptic ulcer (20 duodenal, 10 gastric) underwent glucose-hydrogen (H2) breath tests before and after 6 weeks treatment with cimetidine, 400 mg twice daily. For the group as a whole, basal breath H2 and integrated H2 output over a 2.5 hr test period was unchanged by cimetidine treatment. We conclude that there was no evidence of significant gastric bacterial colonization following twice daily cimetidine treatment.
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Selected References
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- Levitt M. D., Ingelfinger F. J. Hydrogen and methane production in man. Ann N Y Acad Sci. 1968 Feb 26;150(1):75–81. doi: 10.1111/j.1749-6632.1968.tb19033.x. [DOI] [PubMed] [Google Scholar]
- Longstreth G. F., Go V. L., Malagelada J. R. Cimetidine suppression of nocturnal gastric secretion in active duodenal ulcer. N Engl J Med. 1976 Apr 8;294(15):801–804. doi: 10.1056/NEJM197604082941502. [DOI] [PubMed] [Google Scholar]
- Metz G., Gassull M. A., Drasar B. S., Jenkins D. J., Blendis L. M. Breath-hydrogen test for small-intestinal bacterial colonisation. Lancet. 1976 Mar 27;1(7961):668–669. doi: 10.1016/s0140-6736(76)92779-3. [DOI] [PubMed] [Google Scholar]
- Milton-Thompson G. J., Lightfoot N. F., Ahmet Z., Hunt R. H., Barnard J., Bavin P. M., Brimblecombe R. W., Darkin D. W., Moore P. J., Viney N. Intragastric acidity, bacteria, nitrite, and N-nitroso compounds before, during, and after cimetidine treatment. Lancet. 1982 May 15;1(8281):1091–1095. doi: 10.1016/s0140-6736(82)92277-2. [DOI] [PubMed] [Google Scholar]
- Muscroft T. J., Youngs D. J., Burdon D. W., Keighley M. R. Cimetidine is unlikely to increase formation of intragastric N-nitroso-compounds in patients taking a normal diet. Lancet. 1981 Feb 21;1(8217):408–410. doi: 10.1016/s0140-6736(81)91791-8. [DOI] [PubMed] [Google Scholar]
- Muscroft T. J., Youngs D., Burdon D. W., Keighley M. R. Cimetidine and the potential risk of postoperative sepsis. Br J Surg. 1981 Aug;68(8):557–559. doi: 10.1002/bjs.1800680812. [DOI] [PubMed] [Google Scholar]
- Reed P. I., Smith P. L., Haines K., House F. R., Walters C. L. Gastric juice N-nitrosamines in health and gastroduodenal disease. Lancet. 1981 Sep 12;2(8246):550–552. doi: 10.1016/s0140-6736(81)90939-9. [DOI] [PubMed] [Google Scholar]
- Ruddell W. S., Axon A. T., Findlay J. M., Bartholomew B. A., Hill M. J. Effect of cimetidine on the gastric bacterial flora. Lancet. 1980 Mar 29;1(8170):672–674. [PubMed] [Google Scholar]