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. 1984 Oct;60(708):672–674. doi: 10.1136/pgmj.60.708.672

The CREST syndrome--successful reduction of pulmonary hypertension by captopril.

P J Prouse, A Lahiri, J M Gumpel
PMCID: PMC2418051  PMID: 6387690

Abstract

A patient with severe pulmonary hypertension due to pulmonary arteriolar obliteration complicating a long standing CREST variant of systemic sclerosis showed improvement in cardiac output and exercise tolerance during treatment with captopril, which was discontinued because of persistent systemic hypotension. It is suggested that captopril would have a useful and possible prophylactic effect early in pulmonary hypertension in systemic sclerosis.

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Selected References

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  1. Bergofsky E. H. Humoral control of the pulmonary circulation. Annu Rev Physiol. 1980;42:221–233. doi: 10.1146/annurev.ph.42.030180.001253. [DOI] [PubMed] [Google Scholar]
  2. Fries J. F. The microvascular pathogenesis of scleroderma: an hypothesis. Ann Intern Med. 1979 Nov;91(5):788–789. doi: 10.7326/0003-4819-91-5-788. [DOI] [PubMed] [Google Scholar]
  3. Horowitz J. D., Brennan J. B., Oliver L. E., Harding D., Goble A. J., Louis W. J. Effects of captopril (SQ 14,225) in a patient with primary pulmonary hypertension. Postgrad Med J. 1981 Feb;57(664):115–116. doi: 10.1136/pgmj.57.664.115. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Lahiri A., Carboni G. P., Crawley J. W., Raftery E. B. Reversible ischaemia of right ventricle detected by exercise thallium-201 scintigraphy. Br Heart J. 1982 Sep;48(3):260–264. doi: 10.1136/hrt.48.3.260. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Niarchos A. P., Roberts A. J., Laragh J. H. Effects of the converting enzyme inhibitor (SQ 20881) on the pulmonary circulation in man. Am J Med. 1979 Nov;67(5):785–791. doi: 10.1016/0002-9343(79)90735-6. [DOI] [PubMed] [Google Scholar]
  6. Salerni R., Rodnan G. P., Leon D. F., Shaver J. A. Pulmonary hypertension in the CREST syndrome variant of progressive systemic sclerosis (scleroderma). Ann Intern Med. 1977 Apr;86(4):394–399. doi: 10.7326/0003-4819-86-4-394. [DOI] [PubMed] [Google Scholar]
  7. Vrobel T. R., Cohn J. N. Comparative hemodynamic effects of converting enzyme inhibitor and sodium nitroprusside in severe heart failure. Am J Cardiol. 1980 Feb;45(2):331–336. doi: 10.1016/0002-9149(80)90655-4. [DOI] [PubMed] [Google Scholar]
  8. Young R. H., Mark G. J. Pulmonary vascular changes in scleroderma. Am J Med. 1978 Jun;64(6):998–1004. doi: 10.1016/0002-9343(78)90455-2. [DOI] [PubMed] [Google Scholar]
  9. Zawada E. T., Jr, Clements P. J., Furst D. A., Bloomer H. A., Paulus H. E., Maxwell M. H. Clinical course of patients with scleroderma renal crisis treated with captopril. Nephron. 1981;27(2):74–78. doi: 10.1159/000182028. [DOI] [PubMed] [Google Scholar]

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