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. 1985 May;61(715):419–421. doi: 10.1136/pgmj.61.715.419

Ventricular arrhythmias complicating weight reduction therapy in a patient with a prolonged QT interval.

J C O'Keefe, G S Butrous, D S Dymond, P Littlejohns, N Peters, S O Banim
PMCID: PMC2418262  PMID: 4022878

Abstract

Serious ventricular arrhythmias are known to occur in patients with long QT intervals. We describe a case of torsade de pointes occurring in a patient with a prolonged QT interval while taking a 1000 calorie diet, diethylpropion hydrochloride (Tenuate Dospan) and bendrofluazide. In patients with long QT intervals, hypokalaemia and drugs which further delay repolarization may facilitate the development of life threatening arrhythmias.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brown J. M., Yetter J. F., Spicer M. J., Jones J. D. Cardiac complications of protein-sparing modified fasting. JAMA. 1978 Jul 14;240(2):120–122. [PubMed] [Google Scholar]
  2. Curry P., Fitchett D., Stubbs W., Krikler D. Ventricular arrhythmias and hypokalaemia. Lancet. 1976 Jul 31;2(7979):231–233. doi: 10.1016/s0140-6736(76)91029-1. [DOI] [PubMed] [Google Scholar]
  3. Curry P., Fitchett D., Stubbs W., Krikler D. Ventricular arrhythmias and hypokalaemia. Lancet. 1976 Jul 31;2(7979):231–233. doi: 10.1016/s0140-6736(76)91029-1. [DOI] [PubMed] [Google Scholar]
  4. Fowler N. O., McCall D., Chou T. C., Holmes J. C., Hanenson I. B. Electrocardiographic changes and cardiac arrhythmias in patients receiving psychotropic drugs. Am J Cardiol. 1976 Feb;37(2):223–230. doi: 10.1016/0002-9149(76)90316-7. [DOI] [PubMed] [Google Scholar]
  5. Isner J. M., Sours H. E., Paris A. L., Ferrans V. J., Roberts W. C. Sudden, unexpected death in avid dieters using the liquid-protein-modified-fast diet. Observations in 17 patients and the role of the prolonged QT interval. Circulation. 1979 Dec;60(6):1401–1412. doi: 10.1161/01.cir.60.6.1401. [DOI] [PubMed] [Google Scholar]
  6. JERVELL A., LANGE-NIELSEN F. Congenital deaf-mutism, functional heart disease with prolongation of the Q-T interval and sudden death. Am Heart J. 1957 Jul;54(1):59–68. doi: 10.1016/0002-8703(57)90079-0. [DOI] [PubMed] [Google Scholar]
  7. Khan M. M., Logan K. R., McComb J. M., Adgey A. A. Management of recurrent ventricular tachyarrhythmias associated with Q-T prolongation. Am J Cardiol. 1981 Jun;47(6):1301–1308. doi: 10.1016/0002-9149(81)90263-0. [DOI] [PubMed] [Google Scholar]
  8. Kossmann C. E. Torsade de pointes: an addition to the nosography of ventricular tachycardia. Am J Cardiol. 1978 Dec;42(6):1054–1056. doi: 10.1016/0002-9149(78)90695-1. [DOI] [PubMed] [Google Scholar]
  9. Krikler D. M., Curry P. V. Torsade De Pointes, an atypical ventricular tachycardia. Br Heart J. 1976 Feb;38(2):117–120. doi: 10.1136/hrt.38.2.117. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Meltzer R. S., Robert E. W., McMorrow M., Martin R. P. Atypical ventricular tachycardia as a manifestation of disopyramide toxicity. Am J Cardiol. 1978 Dec;42(6):1049–1053. doi: 10.1016/0002-9149(78)90694-x. [DOI] [PubMed] [Google Scholar]
  11. Schreiber E. C., Min B. H., Zeiger A. V., Lang J. F. Metabolism of diethylpropion-1-C14 hydrochloride by the human. J Pharmacol Exp Ther. 1968 Feb;159(2):372–378. [PubMed] [Google Scholar]
  12. Soffer J., Dreifus L. S., Michelson E. L. Polymorphous ventricular tachycardia associated with normal and long Q-T intervals. Am J Cardiol. 1982 Jun;49(8):2021–2029. doi: 10.1016/0002-9149(82)90224-7. [DOI] [PubMed] [Google Scholar]

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