Abstract
The serum half-life of gentamicin following an intravenous dose was compared between 19 pregnant women (28-34 weeks of pregnancy) with premature rupture of the membranes and 17 non-pregnant women with pelvic inflammatory disease, the groups being age and weight matched. A significant reduction of gentamicin half-life was found in the pregnant group.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Cutler R. E., Gyselynck A. M., Fleet W. P., Forrey A. W. Correlation of serum creatinine concentration and gentamicin half-life. JAMA. 1972 Feb 21;219(8):1037–1041. [PubMed] [Google Scholar]
- Landers D. V., Green J. R., Sweet R. L. Antibiotic use during pregnancy and the postpartum period. Clin Obstet Gynecol. 1983 Jun;26(2):391–406. doi: 10.1097/00003081-198306000-00021. [DOI] [PubMed] [Google Scholar]
- McHenry M. C., Gavan T. L., Gifford R. W., Jr, Geurkink N. A., Van Ommen R. A., Town M. A., Wagner J. G. Gentamicin dosages for renal insufficiency. Adjustments based on endogenous creatinine clearance and serum creatinine concentration. Ann Intern Med. 1971 Feb;74(2):192–197. doi: 10.7326/0003-4819-74-2-192. [DOI] [PubMed] [Google Scholar]
