Abstract
Plasma potassium and sodium concentrations were measured in a group of elderly patients taking maintenance thiazide diuretic therapy alone, with a potassium supplement or in combination with a potassium sparing diuretic. Fixed dose combinations of a thiazide and potassium sparing diuretic did not significantly reduce the prevalence of hypokalaemia and the combination of amiloride-hydrochlorothiazide was associated with a disproportionate number of cases of hyponatraemia. The desirability of the current widespread use of fixed dose combination diuretics over less expensive single agents is questioned.
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Selected References
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- Antcliff A. C., Hamilton M., Beevers D. G., Harpur J. E. Amiloride hydrochloride combined with hydrochlorothiazide in the control of hypertension and plasma potassium levels. Br J Clin Pract. 1972 Sep;26(9):413–416. [PubMed] [Google Scholar]
- Beermann B., Groschinsky-Grind M. Pharmacokinetics of hydrochlorothiazide in man. Eur J Clin Pharmacol. 1977 Dec 2;12(4):297–303. doi: 10.1007/BF00607430. [DOI] [PubMed] [Google Scholar]
- Cogan E., Abramow M. Diuretic-induced hyponatraemia in elderly hypertensive women. Lancet. 1983 Nov 26;2(8361):1249–1249. doi: 10.1016/s0140-6736(83)91292-8. [DOI] [PubMed] [Google Scholar]
- Jaffey L., Martin A. Malignant hyperkalaemia after amiloride/hydrochlorothiazide treatment. Lancet. 1981 Jun 6;1(8232):1272–1272. doi: 10.1016/s0140-6736(81)92450-8. [DOI] [PubMed] [Google Scholar]
- Krakauer R., Lauritzen M. Diuretic therapy and hypokalemia in geriatric out-patients. Dan Med Bull. 1978 Apr;25(3):126–129. [PubMed] [Google Scholar]
- Law R., Chalmers C. Medicines and elderly people: a general practice survey. Br Med J. 1976 Mar 6;1(6009):565–568. doi: 10.1136/bmj.1.6009.565. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Millson D., Borland C., Murphy P., Davison W. Hyponatraemia and Moduretic (amiloride plus hydrochlorothiazide) Br Med J (Clin Res Ed) 1984 Nov 10;289(6454):1308–1309. doi: 10.1136/bmj.289.6454.1308-d. [DOI] [PMC free article] [PubMed] [Google Scholar]
- New drugs: modern diuretic treatment. Br Med J (Clin Res Ed) 1983 Jun 18;286(6382):1971–1972. [PMC free article] [PubMed] [Google Scholar]
- Penhall R. K., Frewin D. B. Plasma potassium levels in hypertensive patients receiving fixed-combination diuretic therapy. Med J Aust. 1980 Apr 19;1(8):376–378. doi: 10.5694/j.1326-5377.1980.tb134930.x. [DOI] [PubMed] [Google Scholar]
- Sunderam S. G., Mankikar G. D. Hyponatraemia in the elderly. Age Ageing. 1983 Feb;12(1):77–80. doi: 10.1093/ageing/12.1.77. [DOI] [PubMed] [Google Scholar]
- Williamson J., Chopin J. M. Adverse reactions to prescribed drugs in the elderly: a multicentre investigation. Age Ageing. 1980 May;9(2):73–80. doi: 10.1093/ageing/9.2.73. [DOI] [PubMed] [Google Scholar]