Abstract
Four new moniliformin-producing species of Fusarium were found, viz., F. acuminatum, F. concolor, F. equiseti, and F. semitectum. Isolates of F. acuminatum and F. concolor produced large amounts of moniliformin (3.4 and 9.5 g/kg, respectively), whereas isolates of the other three species yielded less than 30 mg/kg. The production of moniliformin by isolates of F. oxysporum and F. avenaceum from southern Africa is described. All 14 toxic isolates of F. oxysporum produced moniliformin. Most isolates of F. fusarioides and all six isolates of Fusarium moniliforme va. subglutinans tested produced moniliformin, as did 28 of 36 toxic isolates of F. moniliforme. A number of F. moniliforme isolates produced greater than 10 g/kg, and one isolate yielded 33.7 g/kg in corn after incubation for 5 weeks at 25 degrees C. Moniliformin production in the field in corn ears was shown by inoculating plants with known moniliformin-producing isolates of three Fusarium species. Yields of up to 645 mg/kg were recorded. Isolates of F. acuminatum, F. equiseti, F. fusarioides, and F. moniliforme were found that were highly toxic to ducklings but which did not produce moniliformin.
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- Burmeister H. R., Ciegler A., Vesonder R. F. Moniliformin, a metabolite of Fusarium moniliforme NRRL 6322: purification and toxicity. Appl Environ Microbiol. 1979 Jan;37(1):11–13. doi: 10.1128/aem.37.1.11-13.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Burmeister H. R., Grove M. D., Kwolek W. F. Moniliformin and butenolide: effect on mice of high-level, long-term oral intake. Appl Environ Microbiol. 1980 Dec;40(6):1142–1144. doi: 10.1128/aem.40.6.1142-1144.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Burmeister H. R., Vesonder R. F., Kwolek W. F. Mouse bioassay for Fusarium metabolites: rejection or acceptance when dissolved in drinking water. Appl Environ Microbiol. 1980 May;39(5):957–961. doi: 10.1128/aem.39.5.957-961.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cole R. J., Kirksey J. W., Cutler H. G., Doupnik B. L., Peckham J. C. Toxin from Fusarium moniliforme: Effects on Plants and Animals. Science. 1973 Mar 30;179(4080):1324–1326. doi: 10.1126/science.179.4080.1324. [DOI] [PubMed] [Google Scholar]
- Kriek N. P., Marasas W. F., Steyn P. S., van Rensburg S. J., Steyn M. Toxicity of a moniliformin-producing strain of Fusarium moniliforme var. subglutinans isolated from maize. Food Cosmet Toxicol. 1977 Dec;15(6):579–587. doi: 10.1016/0015-6264(77)90073-6. [DOI] [PubMed] [Google Scholar]
- Lansden J. A., Clarkson R. J., Neely W. C., Cole R. J., Kirksey J. W. Spectroanalytical parameters of fungal metabolites. IV. Moniliformin. J Assoc Off Anal Chem. 1974 Nov;57(6):1392–1396. [PubMed] [Google Scholar]
- Rabie C. J., Lübben A., Louw A. I., Rathbone E. B., Steyn P. S., Vleggaar R. Moniliformin, a mycotoxin from Fusarium fusarioides. J Agric Food Chem. 1978 Mar-Apr;26(2):375–379. doi: 10.1021/jf60216a011. [DOI] [PubMed] [Google Scholar]
- Springer J. P., Clardy J., Cole R. J., Kirksey J. W., Hill R. K., Carlson M. R., Isidor J. L. Structure and synthesis of moniliformin, a novel cyclobutane microbial toxin. J Am Chem Soc. 1974 Apr 3;96(7):2267–2268. doi: 10.1021/ja00814a055. [DOI] [PubMed] [Google Scholar]
- Steyn M., Thiel P. G., van Schalkwyk G. C. Isolation and purification of moniliformin. J Assoc Off Anal Chem. 1978 May;61(3):578–580. [PubMed] [Google Scholar]
- Thiel P. G. A molecular mechanism for the toxic action of moniliformin, a mycotoxin produced by Fusarium moniliforme. Biochem Pharmacol. 1978 Feb 15;27(4):483–486. doi: 10.1016/0006-2952(78)90381-7. [DOI] [PubMed] [Google Scholar]
- Wehner F. C., Marasas W. F., Thiel P. G. Lack of mutagenicity to Salmonella typhimurium of some Fusarium mycotoxins. Appl Environ Microbiol. 1978 Apr;35(4):659–662. doi: 10.1128/aem.35.4.659-662.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]