Abstract
The results of indium-111 tropolonate leucocyte scintigraphy in 105 patients with known inflammatory bowel disease are reviewed. Scintigraphy is as sensitive as radiology in detecting and assessing the extent of active colonic disease, and probably more sensitive in assessing small bowel disease. In a further 40 patients scintigraphy was successfully used as a screening test to identify, or exclude, bowel inflammation in patients with gastrointestinal symptoms. Scintigraphy has advantages over barium studies, being safe, non-invasive, more sensitive than small bowel radiology and giving additional information such as the bowel identification of intra-abdominal abscesses. The time required to label the leucocytes (about 2 hours) and the higher unit cost, unless many scintigrams are performed, are disadvantages.
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- Bjarnason I., Williams P., So A., Zanelli G. D., Levi A. J., Gumpel J. M., Peters T. J., Ansell B. Intestinal permeability and inflammation in rheumatoid arthritis: effects of non-steroidal anti-inflammatory drugs. Lancet. 1984 Nov 24;2(8413):1171–1174. doi: 10.1016/s0140-6736(84)92739-9. [DOI] [PubMed] [Google Scholar]
- Jones V. A., Dickinson R. J., Workman E., Wilson A. J., Freeman A. H., Hunter J. O. Crohn's disease: maintenance of remission by diet. Lancet. 1985 Jul 27;2(8448):177–180. doi: 10.1016/s0140-6736(85)91497-7. [DOI] [PubMed] [Google Scholar]
- Saverymuttu S. H., Crofton M. E., Peters A. M., Lavender J. P. Indium-111 tropolonate leucocyte scanning in the detection of intra-abdominal abscesses. Clin Radiol. 1983 Sep;34(5):593–596. doi: 10.1016/s0009-9260(83)80176-7. [DOI] [PubMed] [Google Scholar]
- Saverymuttu S. H., Peters A. M., Crofton M. E., Rees H., Lavender J. P., Hodgson H. J., Chadwick V. S. 111Indium autologous granulocytes in the detection of inflammatory bowel disease. Gut. 1985 Sep;26(9):955–960. doi: 10.1136/gut.26.9.955. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Saverymuttu S. H., Peters A. M., Hodgson H. J., Chadwick V. S., Lavender J. P. 111Indium leukocyte scanning in small-bowel Crohn's disease. Gastrointest Radiol. 1983;8(2):157–161. doi: 10.1007/BF01948113. [DOI] [PubMed] [Google Scholar]
- Saverymuttu S. H., Peters A. M., Hodgson H. J., Chadwick V. S., Lavender J. P. Indium-111 autologous leucocyte scanning: comparison with radiology for imaging the colon in inflammatory bowel disease. Br Med J (Clin Res Ed) 1982 Jul 24;285(6337):255–257. doi: 10.1136/bmj.285.6337.255. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Saverymuttu S. H., Peters A. M., Lavender J. P., Pepys M. B., Hodgson H. J., Chadwick V. S. Quantitative fecal indium 111-labeled leukocyte excretion in the assessment of disease in Crohn's disease. Gastroenterology. 1983 Dec;85(6):1333–1339. [PubMed] [Google Scholar]
- Stein D. T., Gray G. M., Gregory P. B., Anderson M., Goodwin D. A., McDougall I. R. Location and activity of ulcerative and Crohn's colitis by indium 111 leukocyte scan. A prospective comparison study. Gastroenterology. 1983 Feb;84(2):388–393. [PubMed] [Google Scholar]
- TRUELOVE S. C., WITTS L. J. Cortisone in ulcerative colitis; final report on a therapeutic trial. Br Med J. 1955 Oct 29;2(4947):1041–1048. doi: 10.1136/bmj.2.4947.1041. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Thakur M. L., Lavender J. P., Arnot R. N., Silvester D. J., Segal A. W. Indium-111-labeled autologous leukocytes in man. J Nucl Med. 1977 Oct;18(10):1014–1021. [PubMed] [Google Scholar]
- Thakur M. L., McAfee J. G. The significance of chromosomal aberrations in indium-111-labeled lymphocytes. J Nucl Med. 1984 Aug;25(8):922–927. [PubMed] [Google Scholar]