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. 1986 Aug;62(730):773–776. doi: 10.1136/pgmj.62.730.773

Colitis caused by non-steroidal anti-inflammatory drugs.

S Ravi, A C Keat, E C Keat
PMCID: PMC2418853  PMID: 3774712

Abstract

Four cases of acute proctocolitis associated with non-steroidal anti-inflammatory drug therapy are presented. The drugs implicated were flufenamic acid, mefenamic acid, naproxen and ibuprofen. After resolution of symptoms and signs of proctocolitis three of the four patients were subsequently rechallenged with the implicated drug: in each there was a rapid relapse.

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Selected References

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  1. Atherton L. D., Leib E. S., Kaye M. D. Toxic megacolon associated with methotrexate therapy. Gastroenterology. 1984 Jun;86(6):1583–1588. [PubMed] [Google Scholar]
  2. Bjarnason I., Williams P., So A., Zanelli G. D., Levi A. J., Gumpel J. M., Peters T. J., Ansell B. Intestinal permeability and inflammation in rheumatoid arthritis: effects of non-steroidal anti-inflammatory drugs. Lancet. 1984 Nov 24;2(8413):1171–1174. doi: 10.1016/s0140-6736(84)92739-9. [DOI] [PubMed] [Google Scholar]
  3. Collins J. P. Cimetidine-induced acute ulcerative colitis. Med J Aust. 1982 Apr 3;1(7):307–307. doi: 10.5694/j.1326-5377.1982.tb132318.x. [DOI] [PubMed] [Google Scholar]
  4. Coutrot S., Roland D., Barbier J., Van Der Marcq P., Alcalay M., Matuchansky C. Acute perforation of colonic diverticula associated with short-term indomethacin. Lancet. 1978 Nov 11;2(8098):1055–1056. doi: 10.1016/s0140-6736(78)92385-1. [DOI] [PubMed] [Google Scholar]
  5. Enteritis and colitis associated with mefenamic acid. Br Med J (Clin Res Ed) 1983 Nov 26;287(6405):1626–1627. doi: 10.1136/bmj.287.6405.1626. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Fam A. G., Paton T. W., Shamess C. J., Lewis A. J. Fulminant colitis complicating gold therapy. J Rheumatol. 1980 Jul-Aug;7(4):479–485. [PubMed] [Google Scholar]
  7. Graham C. F., Gallagher K., Jones J. K. Acute colitis with methyldopa. N Engl J Med. 1981 Apr 23;304(17):1044–1045. [PubMed] [Google Scholar]
  8. Hall R. I., Petty A. H., Cobden I., Lendrum R. Enteritis and colitis associated with mefenamic acid. Br Med J (Clin Res Ed) 1983 Oct 22;287(6400):1182–1182. doi: 10.1136/bmj.287.6400.1182. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Hawkey C. J., Lo Casto M. Inhibition of prostaglandin synthetase in human rectal mucosa. Gut. 1983 Mar;24(3):213–217. doi: 10.1136/gut.24.3.213. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Hickling P., Fuller J. Penicillamine causing acute colitis. Br Med J. 1979 Aug 11;2(6186):367–367. doi: 10.1136/bmj.2.6186.367. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Levy N., Gaspar E. Letter: Rectal bleeding and indomethacin suppositories. Lancet. 1975 Mar 8;1(7906):577–577. doi: 10.1016/s0140-6736(75)91600-1. [DOI] [PubMed] [Google Scholar]
  12. Pearson D. J., Stones N. A., Bentley S. J. Proctocolitis induced by salicylate and associated with asthma and recurrent nasal polyps. Br Med J (Clin Res Ed) 1983 Dec 3;287(6406):1675–1675. doi: 10.1136/bmj.287.6406.1675. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Rampton D. S., Sladen G. E. Prostaglandin synthesis inhibitors in ulcerative colitis: flurbiprofen compared with conventional treatment. Prostaglandins. 1981 Mar;21(3):417–425. doi: 10.1016/0090-6980(81)90087-3. [DOI] [PubMed] [Google Scholar]
  14. Rampton D. S., Sladen G. E. Relapse of ulcerative proctocolitis during treatment with non-steroidal anti-inflammatory drugs. Postgrad Med J. 1981 May;57(667):297–299. doi: 10.1136/pgmj.57.667.297. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Robert A. Cytoprotection by prostaglandins. Gastroenterology. 1979 Oct;77(4 Pt 1):761–767. [PubMed] [Google Scholar]
  16. Schwartz H. A. Lower gastrointestinal side effects of nonsteroidal antiinflammatory drugs. J Rheumatol. 1981 Nov-Dec;8(6):952–954. [PubMed] [Google Scholar]
  17. Sharon P., Ligumsky M., Rachmilewitz D., Zor U. Role of prostaglandins in ulcerative colitis. Enhanced production during active disease and inhibition by sulfasalazine. Gastroenterology. 1978 Oct;75(4):638–640. [PubMed] [Google Scholar]
  18. Tanser A. R., Keat E. C. Phenindione-induced haemorrhagic ulcerative colitis. Br Med J. 1966 Mar 5;1(5487):588–588. doi: 10.1136/bmj.1.5487.588. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Tedesco F. J., Volpicelli N. A., Moore F. S. Estrogen- and progesterone-associated colitis: a disorder with clinical and endoscopic features mimicking Crohn's colitis. Gastrointest Endosc. 1982 Nov;28(4):247–249. doi: 10.1016/s0016-5107(82)73102-5. [DOI] [PubMed] [Google Scholar]
  20. Vane J. R. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nat New Biol. 1971 Jun 23;231(25):232–235. doi: 10.1038/newbio231232a0. [DOI] [PubMed] [Google Scholar]
  21. Walt R. P., Hawkey C. J., Langman M. J. Colitis associated with non-steroidal anti-inflammatory drugs. Br Med J (Clin Res Ed) 1984 Jan 21;288(6412):238–238. doi: 10.1136/bmj.288.6412.238-a. [DOI] [PMC free article] [PubMed] [Google Scholar]

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