Skip to main content
Postgraduate Medical Journal logoLink to Postgraduate Medical Journal
. 1986 Nov;62(733):1059–1060. doi: 10.1136/pgmj.62.733.1059

Successful treatment of scleroderma renal crisis with enalapril.

S R Milsom, M G Nicholls
PMCID: PMC2418962  PMID: 2819841

Abstract

A patient with scleroderma renal crisis is described. At presentation he had severe hypertension, deteriorating renal function, microangiopathic haemolytic anaemia, and elevated levels of renin, aldosterone and noradrenaline. Enalapril controlled blood pressure, stabilized renal function, lowered aldosterone and noradrenaline levels, and improved peripheral circulation. It appears that converting-enzyme inhibitors can favourably alter the outlook of this otherwise fatal disorder.

Full text

PDF
1059

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barnett A. J. Medical treatment of hypertension and renal failure in scleroderma. Aust N Z J Med. 1981 Aug;11(4):411–415. doi: 10.1111/j.1445-5994.1981.tb03523.x. [DOI] [PubMed] [Google Scholar]
  2. Lopez-Ovejero J. A., Saal S. D., D'Angelo W. A., Cheigh J. S., Stenzel K. H., Laragh J. H. Reversal of vascular and renal crises of scleroderma by oral angiotensin-converting-enzyme blockade. N Engl J Med. 1979 Jun 21;300(25):1417–1419. doi: 10.1056/NEJM197906213002505. [DOI] [PubMed] [Google Scholar]
  3. Smith C. D., Smith R. D., Korn J. H. Hypertensive crisis in systemic sclerosis: treatment with the new oral angiotensin converting enzyme inhibitor MK, 421 (Enalapril) in captopril-intolerant patients. Arthritis Rheum. 1984 Jul;27(7):826–828. doi: 10.1002/art.1780270716. [DOI] [PubMed] [Google Scholar]
  4. Thurm R. H., Alexander J. C. Captopril in the treatment of scleroderma renal crisis. Arch Intern Med. 1984 Apr;144(4):733–735. [PubMed] [Google Scholar]
  5. Traub Y. M., Shapiro A. P., Rodnan G. P., Medsger T. A., McDonald R. H., Jr, Steen V. D., Osial T. A., Jr, Tolchin S. F. Hypertension and renal failure (scleroderma renal crisis) in progressive systemic sclerosis. Review of a 25-year experience with 68 cases. Medicine (Baltimore) 1983 Nov;62(6):335–352. doi: 10.1097/00005792-198311000-00001. [DOI] [PubMed] [Google Scholar]

Articles from Postgraduate Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES