Abstract
Fungal transformations of triparanol, a hypercholesterolemic drug, were studied in Lagenidium giganteum and Lagenidium callinectes. The products were identified by combined gas chromatography-mass spectrometry. Two metabolites were observed from each organism; only one of the metabolites was found in both organisms.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- ANDERSEN S. O. THE CROSS-LINKS IN RESILIN IDENTIFIED AS DITYROSINE AND TRITYROSINE. Biochim Biophys Acta. 1964 Oct 9;93:213–215. doi: 10.1016/0304-4165(64)90289-2. [DOI] [PubMed] [Google Scholar]
- AVIGAN J., STEINBERG D., VROMAN H. E., THOMPSON M. J., MOSETTIG E. Studies of cholesterol biosynthesis. I. The identification of desmosterol in serum and tissues of animals and man treated with MER-29. J Biol Chem. 1960 Nov;235:3123–3126. [PubMed] [Google Scholar]
- Patterson G. W., Doyle P. J., Dickson L. G., Chan J. T. Effects of triparanol and AY-9944 upon sterol biosynthesis in Chorella. Lipids. 1974 Aug;9(8):567–574. doi: 10.1007/BF02532506. [DOI] [PubMed] [Google Scholar]
- Svoboda J. A., Robbins W. E. Conversion of beta sitosterol to cholesterol blocked in an insect by hypocholesterolemic agents. Science. 1967 Jun 23;156(3782):1637–1638. doi: 10.1126/science.156.3782.1637. [DOI] [PubMed] [Google Scholar]