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. 1983 Feb;45(2):665–668. doi: 10.1128/aem.45.2.665-668.1983

Inhibition of Naegleria fowleri by microbial iron-chelating agents: ecological implications.

A L Newsome, W E Wilhelm
PMCID: PMC242341  PMID: 6830222

Abstract

Deferrioxamine B and rhodotorulic acid, iron-chelating agents of microbial origin, exerted a pronounced inhibitory effect on pathogenic Naegleria fowleri at microgram levels. This inhibition was diminished by adding iron to the chelators before incubation with Naegleria isolates. These and related microbial iron chelators occur naturally in the environment. This could be of considerable ecological significance and provides a novel hypothesis to account for the proliferation of pathogenic Naegleria spp. in certain aquatic habitats.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Band R. N., Balamuth W. Hemin replaces serum as a growth requirement for Naegleria. Appl Microbiol. 1974 Jul;28(1):64–65. doi: 10.1128/am.28.1.64-65.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Butt C. G. Primary amebic meningoencephalitis. N Engl J Med. 1966 Jun 30;274(26):1473–1476. doi: 10.1056/NEJM196606302742605. [DOI] [PubMed] [Google Scholar]
  3. Chang S. L. Pathogenesis of pathogenic Naegleria amoeba. Folia Parasitol (Praha) 1979;26(3):195–200. [PubMed] [Google Scholar]
  4. Chang S. L. Small, free-living amebas: cultivation, quantitation, identification, classification, pathogenesis, and resistance. Curr Top Comp Pathobiol. 1971;1:201–254. doi: 10.1016/b978-0-12-153401-1.50010-7. [DOI] [PubMed] [Google Scholar]
  5. De Jonckheere J. Use of an axenic medium for differentiation between pathogenic and nonpathogenic Naegleria fowleri isolates. Appl Environ Microbiol. 1977 Apr;33(4):751–757. doi: 10.1128/aem.33.4.751-757.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Dive D. G., Leclerc H., De Jonckheere J., Delattre J. M. Isolation of Naegleria fowleri from the cooling pond of an electric power plant in France. Ann Microbiol (Paris) 1981 Jan-Feb;132A(1):97–105. [PubMed] [Google Scholar]
  7. Duma R. J., Shumaker J. B., Callicott J. H., Jr Primary amebic meningoencephalitis. A survey in Virginia. Arch Environ Health. 1971 Jul;23(1):43–47. doi: 10.1080/00039896.1971.10665953. [DOI] [PubMed] [Google Scholar]
  8. Garibaldi J. A. Influence of temperature on the biosynthesis of iron transport compounds by Salmonella typhimurium. J Bacteriol. 1972 Apr;110(1):262–265. doi: 10.1128/jb.110.1.262-265.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Garibaldi J. A. Influence of temperature on the iron metabolism of a fluorescent pseudomonad. J Bacteriol. 1971 Mar;105(3):1036–1038. doi: 10.1128/jb.105.3.1036-1038.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Mandal B. N., Gudex D. J., Fitchett M. R., Pullon D. H., Malloch J. A., David C. M., Apthorp J. Acute meningo-encephalitis due to amoebae of the order myxomycetale (slime mould). N Z Med J. 1970 Jan;71(452):16–23. [PubMed] [Google Scholar]
  11. Martinez A. J., Nelson E. C., Jones M. M., Duma R. J., Rosenblum W. I. Experimental Naegleria meningoencephalitis in mice. An electron microscope study. Lab Invest. 1971 Nov;25(5):465–475. [PubMed] [Google Scholar]
  12. Murphy T. P., Lean D. R., Nalewajko C. Blue-green algae: their excretion of iron-selective chelators enables them to dominate other algae. Science. 1976 May 28;192(4242):900–902. doi: 10.1126/science.818707. [DOI] [PubMed] [Google Scholar]
  13. Newsome A. L., Wilhelm W. E. Effect of exogenous iron on the viability of pathogenic Naegleria fowleri in serum. Experientia. 1981 Nov 15;37(11):1160–1162. doi: 10.1007/BF01989894. [DOI] [PubMed] [Google Scholar]
  14. O'Dell W. D., Stevens A. R. Quantitative growth of Naegleria in axenic culture. Appl Microbiol. 1973 Apr;25(4):621–627. doi: 10.1128/am.25.4.621-627.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Page F. C. Taxonomic criteria for limax amoebae, with descriptions of 3 new species of Hartmannella and 3 of Vahlkampfia. J Protozool. 1967 Aug;14(3):499–521. doi: 10.1111/j.1550-7408.1967.tb02036.x. [DOI] [PubMed] [Google Scholar]
  16. Stevens A. R., Shulman S. T., Lansen T. A., Cichon M. J., Willaert E. Primary amoebic meningoencephalitis: a report of two cases and antibiotic and immunologic studies. J Infect Dis. 1981 Feb;143(2):193–199. doi: 10.1093/infdis/143.2.193. [DOI] [PubMed] [Google Scholar]
  17. Stevens A. R., Tyndall R. L., Coutant C. C., Willaert E. Isolation of the etiological agent of primary amoebic meningoencephalitis from artifically heated waters. Appl Environ Microbiol. 1977 Dec;34(6):701–705. doi: 10.1128/aem.34.6.701-705.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Van den Driessche E., Vandepitte J., Van Dijck P. J., De Jonckheere J., Van de Voorde H. Letter: Primary amoebic meningoencephalitis after swimming in stream water. Lancet. 1973 Oct 27;2(7835):971–971. doi: 10.1016/s0140-6736(73)92634-2. [DOI] [PubMed] [Google Scholar]
  19. Wellings F. M., Amuso P. T., Chang S. L., Lewis A. L. Isolation and identification of pathogenic Naegleria from Florida lakes. Appl Environ Microbiol. 1977 Dec;34(6):661–667. doi: 10.1128/aem.34.6.661-667.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Willaert E., Jamieson A., Jadin J. B., Anderson K. Epidemiological and immunoelectrophoretic studies on human and environmental strains of Naegleria fowleri. Ann Soc Belg Med Trop. 1974;54(4-5):333–342. [PubMed] [Google Scholar]
  21. de Jonckheere J., Voorde H. The distribution of Naegleria fowleri in man-made thermal waters. Am J Trop Med Hyg. 1977 Jan;26(1):10–15. doi: 10.4269/ajtmh.1977.26.10. [DOI] [PubMed] [Google Scholar]

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