Skip to main content
Applied and Environmental Microbiology logoLink to Applied and Environmental Microbiology
. 1983 May;45(5):1486–1490. doi: 10.1128/aem.45.5.1486-1490.1983

Biosynthesis of penitrems and roquefortine by Penicillium crustosum.

P G Mantle, K P Perera, N J Maishman, G R Mundy
PMCID: PMC242489  PMID: 6870239

Abstract

Roquefortine and the penitrems were biosynthesised concurrently at an approximately equimolar rate by Penicillium crustosum after growth and sporulation. [14C]mevalonic acid was incorporated (15% efficiency) into the isoprenoid regions of the penitrem and roquefortine molecules to an extent consistent with their 6:1 molar ratio of isoprenoid components. [14C]penitrem A (specific activity, 3.4 X 10(2) mu Ci mmol-1) and 14C-penitrems B, C, and E readministered to young cultures were metabolically interconverted, indicating considerable metabolic flux, though generally directed towards penitrem A as the end product and suggesting a metabolic grid for the penitrem metabolites. Addition of bromide to the medium preferentially favored the production of bromo-analogs rather than the usual chloropenitrems.

Full text

PDF
1486

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Day J. B., Mantle P. G., Shaw B. I. Production of verruculogen by Penicillium estinogenum in stirred fermenters. J Gen Microbiol. 1980 Apr;117(2):405–410. doi: 10.1099/00221287-117-2-405. [DOI] [PubMed] [Google Scholar]
  2. Hou C. T., Ciegler A., Hesseltine C. W. Tremorgenic toxins from Penicillia. I. Colorimetric determination of tremortins A and B. Anal Biochem. 1970 Oct;37(2):422–428. doi: 10.1016/0003-2697(70)90068-0. [DOI] [PubMed] [Google Scholar]
  3. Kyriakidis N., Waight E. S., Day J. B., Mantle P. G. Novel metabolites from Penicillium crustosum, including penitrem E, a tremorgenic mycotoxin. Appl Environ Microbiol. 1981 Jul;42(1):61–62. doi: 10.1128/aem.42.1.61-62.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Wagener R. E., Davis N. D., Diener U. L. Penitrem A and Roquefortine Production by Penicillium commune. Appl Environ Microbiol. 1980 Apr;39(4):882–887. doi: 10.1128/aem.39.4.882-887.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Applied and Environmental Microbiology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES