Abstract
Patients undergoing biliary surgery received either 750 mg cefuroxime i.m. with the premedication and then 8 hourly for 3 days ((group A) or 1.5 g cefuroxime i.v. at the time of induction of anaesthesia (group B) or not treatment (group C). Wound infections occurred in 3 out of 35 patients in group A, 1 out of 40 patients in group B and 11 out of 39 patients in group C (group B significantly different than group C, P less than 0.05). Eight patients (23%) in group C had chest complications. Cefuroxime was effective in the reduction of wound sepsis following biliary surgery and 1.5 g i.v. administered during induction of anaesthesia is the dosage of choice. The incidence of chest infection tended to be lower in patients receiving cefuroxime but many more patients would have to be studied for a conclusive result.
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Selected References
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- Burke J. F. The effective period of preventive antibiotic action in experimental incisions and dermal lesions. Surgery. 1961 Jul;50:161–168. [PubMed] [Google Scholar]
- Collins C. D., Darke C. S., Knowelden J. Chest complications after upper abdominal surgery: their anticipation and prevention. Br Med J. 1968 Feb 17;1(5589):401–406. doi: 10.1136/bmj.1.5589.401. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hansen G., Drablos P. A., Steinert R. Pulmonary complications, ventilation and blood gases after upper abdominal surgery. Acta Anaesthesiol Scand. 1977;21(3):211–215. doi: 10.1111/j.1399-6576.1977.tb01211.x. [DOI] [PubMed] [Google Scholar]
- Laszlo G., Archer G. G., Darrell J. H., Dawson J. M., Fletcher C. M. The diagnosis and prophylaxis of pulmonary complications of surgical operation. Br J Surg. 1973 Feb;60(2):129–134. doi: 10.1002/bjs.1800600210. [DOI] [PubMed] [Google Scholar]
- Morran C., McNaught W., McArdle C. S. Prophylactic co-trimoxazole in biliary surgery. Br Med J. 1978 Aug 12;2(6135):462–464. doi: 10.1136/bmj.2.6135.462. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Morran C., Mcardle C. S. The reduction of postoperative chest infection by prophylactic co-trimoxazole. Br J Surg. 1980 Jul;67(7):464–466. doi: 10.1002/bjs.1800670704. [DOI] [PubMed] [Google Scholar]
- O'Callaghan C. H., Sykes R. B., Griffiths A., Thornton J. E. Cefuroxime, a new cephalosporin antibiotic: activity in vitro. Antimicrob Agents Chemother. 1976 Mar;9(3):511–519. doi: 10.1128/aac.9.3.511. [DOI] [PMC free article] [PubMed] [Google Scholar]
- doi: 10.1177/00359157770700S902. [DOI] [PMC free article] [Google Scholar]
- Polk H. C., Jr, Lopez-Mayor J. F. Postoperative wound infection: a prospective study of determinant factors and prevention. Surgery. 1969 Jul;66(1):97–103. [PubMed] [Google Scholar]
- Presley A. P., Alexander-Williams J. Postoperative chest infection. Br J Surg. 1974 Jun;61(6):448–452. doi: 10.1002/bjs.1800610608. [DOI] [PubMed] [Google Scholar]
- Stone H. H., Haney B. B., Kolb L. D., Geheber C. E., Hooper C. A. Prophylactic and preventive antibiotic therapy: timing, duration and economics. Ann Surg. 1979 Jun;189(6):691–699. doi: 10.1097/00000658-197906000-00004. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Stone H. H., Hooper C. A., Kolb L. D., Geheber C. E., Dawkins E. J. Antibiotic prophylaxis in gastric, biliary and colonic surgery. Ann Surg. 1976 Oct;184(4):443–452. doi: 10.1097/00000658-197610000-00007. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Strachan C. J., Black J., Powis S. J., Waterworth T. A., Wise R., Wilkinson A. R., Burdon D. W., Severn M., Mitra B., Norcott H. Prophylactic use of cephazolin against wound sepsis after cholecystectomy. Br Med J. 1977 May 14;1(6071):1254–1256. doi: 10.1136/bmj.1.6071.1254. [DOI] [PMC free article] [PubMed] [Google Scholar]