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. 1981 May;57(667):310–313. doi: 10.1136/pgmj.57.667.310

Pyrexia of unknown origin. Presenting sign of hypothalamic hypopituitarism.

R Marilus, A Barkan, S Leiba, R Arie, I Blum
PMCID: PMC2424913  PMID: 7301672

Abstract

A 62-year-old man was admitted to hospital 10 times over 12 years because of pyrexia of unknown origin. Hypothalamic hypopituitarism was diagnosed by dynamic tests including clomiphene, LRH, TRH and chlorpromazine stimulation. Lack of ACTH was demonstrated by long and short tetracosactrin tests. The aetiology of the disorder was believed to be previous encephalitis. Following substitution therapy with adrenal and gonadal steroids there were no further episodes of fever.

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Selected References

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