Skip to main content
NCBI home page
Postgraduate Medical Journal logoLink to Postgraduate Medical Journal
. 1981 Jul;57(669):427–430. doi: 10.1136/pgmj.57.669.427

Anti-hypertensive therapy with propranolol during pregnancy and lactation.

E A Taylor, P Turner
PMCID: PMC2424946  PMID: 7312737

Abstract

A hypertensive women was treated throughout pregnancy with propranolol 40 mg daily without complication. At delivery the umbilical cord plasma concentration was similar to that in the maternal venous plasma. Milk:plasma ratios were less than 1, although a higher ratio would be predicted. Estimated daily intake of propranolol in breast milk by the infant was about 3 micrograms. There appears to be no reason to advise women receiving propranolol to avoid breast feeding.

Full text

PDF
427

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ananth J. Side effects in the neonate from psychotropic agents excreted through breast-feeding. Am J Psychiatry. 1978 Jul;135(7):801–805. doi: 10.1176/ajp.135.7.801. [DOI] [PubMed] [Google Scholar]
  2. Barden T. P., Stander R. W. Effects of adrenergic blocking agents and catecholamines in human pregnancy. Am J Obstet Gynecol. 1968 Sep 15;102(2):226–235. doi: 10.1016/0002-9378(68)90323-2. [DOI] [PubMed] [Google Scholar]
  3. Bauer J. H., Pape B., Zajicek J., Groshong T. Propranolol in human plasma and breast milk. Am J Cardiol. 1979 Apr;43(4):860–862. doi: 10.1016/0002-9149(79)90090-0. [DOI] [PubMed] [Google Scholar]
  4. Bullock J. L., Harris R. E., Young R. Treatment of thyrotoxicosis during pregnancy with propranolol. Am J Obstet Gynecol. 1975 Jan 15;121(2):242–245. doi: 10.1016/0002-9378(75)90648-1. [DOI] [PubMed] [Google Scholar]
  5. Burrow G. N. Hyperthyroidism during pregnancy. N Engl J Med. 1978 Jan 19;298(3):150–153. doi: 10.1056/NEJM197801192980309. [DOI] [PubMed] [Google Scholar]
  6. Cottrill C. M., McAllister R. G., Jr, Gettes L., Noonan J. A. Propranolol therapy during pregnancy, labor, and delivery: evidence for transplacental drug transfer and impaired neonatal drug disposition. J Pediatr. 1977 Nov;91(5):812–814. doi: 10.1016/s0022-3476(77)81049-4. [DOI] [PubMed] [Google Scholar]
  7. Dubois D., Temperville B., Petitcolas J., Klepper A. Bêta-bloquants au cours des grossesses à hauts risques. Nouv Presse Med. 1978 Nov 25;7(41):3769–3769. [PubMed] [Google Scholar]
  8. Gallery E. D., Saunders D. M., Hunyor S. N., Györy A. Z. Improvement in foetal growth with treatment of maternal hypertension in pregnancy. Clin Sci Mol Med Suppl. 1978 Dec;4:359s–361s. doi: 10.1042/cs055359s. [DOI] [PubMed] [Google Scholar]
  9. Gladstone G. R., Hordof A., Gersony W. M. Propranolol administration during pregnancy: effects on the fetus. J Pediatr. 1975 Jun;86(6):962–964. doi: 10.1016/s0022-3476(75)80236-8. [DOI] [PubMed] [Google Scholar]
  10. Habib A., McCarthy J. S. Effects on the neonate of propranolol administered during pregnancy. J Pediatr. 1977 Nov;91(5):808–811. doi: 10.1016/s0022-3476(77)81048-2. [DOI] [PubMed] [Google Scholar]
  11. Karlberg B., Lundberg D., Aberg H. Letter: Excretion of propranolol in human breast milk. Acta Pharmacol Toxicol (Copenh) 1974 Mar;34(3):222–224. [PubMed] [Google Scholar]
  12. Langer A., Hung C. T., Mc A'nulty J. A., Harrigan J. T., Washington E. Adrenergic blockade. A new approach to hyperthyroidism during pregnancy. Obstet Gynecol. 1974 Aug;44(2):181–186. [PubMed] [Google Scholar]
  13. Levitan A. A., Manion J. C. Propranolol therapy during pregnancy and lactation. Am J Cardiol. 1973 Aug;32(2):247–247. [PubMed] [Google Scholar]
  14. McAinsh J., Baber N. S., Smith R., Young J. Pharmacokinetic and pharmacodynamic studies with long-acting propranolol. Br J Clin Pharmacol. 1978 Aug;6(2):115–121. doi: 10.1111/j.1365-2125.1978.tb00835.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Oakley G. D., McGarry K., Limb D. G., Oakley C. M. Management of pregnancy in patients with hypertrophic cardiomyopathy. Br Med J. 1979 Jun 30;1(6180):1749–1750. doi: 10.1136/bmj.1.6180.1749. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. POSE S. V., CIBILS L. A., ZUSPAN F. P. Effect of 1-epinephrine infusion on uterine contractility and cardiovascular system. Am J Obstet Gynecol. 1962 Aug 1;84:297–306. doi: 10.1016/0002-9378(62)90126-6. [DOI] [PubMed] [Google Scholar]
  17. Reed R. L., Cheney C. B., Fearon R. E., Hook R., Hehre F. W. Propranolol therapy throughout pregnancy: a case report. Anesth Analg. 1974 Mar-Apr;53(2):214–214. [PubMed] [Google Scholar]
  18. Schroeder J. S., Harrison D. C. Repeated cardioversion during pregnancy. Treatment of refractory paroxysmal atrial tachycardia during 3 successive pregnancies. Am J Cardiol. 1971 Apr;27(4):445–446. doi: 10.1016/0002-9149(71)90443-7. [DOI] [PubMed] [Google Scholar]
  19. Tcherdakoff P. H., Colliard M., Berrard E., Kreft C., Dupay A., Bernaille J. M. Propranolol in hypertension during pregnancy. Br Med J. 1978 Sep 2;2(6138):670–670. doi: 10.1136/bmj.2.6138.670. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Teuscher A., Bossi E., Imhof P., Erb E., Stocker F. P., Weber J. W. Effect of propranolol on fetal tachycardia in diabetic pregnancy. Am J Cardiol. 1978 Aug;42(2):304–307. doi: 10.1016/0002-9149(78)90916-5. [DOI] [PubMed] [Google Scholar]
  21. Tunstall M. E. The effect of propranolol on the onset of breathing at birth. Br J Anaesth. 1969 Sep;41(9):792–792. [PubMed] [Google Scholar]
  22. Turner G. M., Oakley C. M., Dixon H. G. Management of pregnancy complicated by hypertrophic obstructive cardiomyopathy. Br Med J. 1968 Nov 2;4(5626):281–284. doi: 10.1136/bmj.4.5626.281. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Wansbrough H., Nakanishi H., Wood C. The effect of adrenergic receptor blocking drugs on the human uterus. J Obstet Gynaecol Br Commonw. 1968 Feb;75(2):189–198. doi: 10.1111/j.1471-0528.1968.tb02031.x. [DOI] [PubMed] [Google Scholar]

Articles from Postgraduate Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES