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. 1983 May;45(5):1701–1703. doi: 10.1128/aem.45.5.1701-1703.1983

Oxidation of Two Hydroxylated Ochratoxin A Metabolites by Alcohol Dehydrogenase

Christian Syvertsen 1, Fredrik C Størmer 1
PMCID: PMC242520  PMID: 6347065

Abstract

(4R)-4-hydroxyochratoxin A, (4S)-4-hydroxyochratoxin A, and 10-hydroxyochratoxin A, all formed from ochratoxin A, were incubated with alcohol dehydrogenase in the presence of NAD. Only (4R)-4-hydroxyochratoxin A and 10-hydroxyochratoxin A acted as substrates for the enzyme. Km and turnover number for 10-hydroxyochratoxin A were 110 μM and 0.1 s−1, respectively.

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Selected References

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