Abstract
The laboratory transmission to animals of an apparently degenerative disease of the nervous system, Creutzfeldt-Jakob disease (CJD), is now well established. Important questions arising from this observation are the possibility of natural transmission or infectivity and the existence of other similarly transmissible diseases. Epidemiological studies have revealed some possible clusters of CJD and also an association with previous craniotomy, but there is no definite evidence of natural infection. A few instances have been reported of experimental CJD in animals following inoculation with material from Alzheimer's disease, but apart from this there is so far no evidence of transmission of any other form of degenerative nervous disease.
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- Alter M., Frank Y., Doyne H., Webster D. D. Letter: Creutzfeldt--Jakob disease after eating ovine brains? N Engl J Med. 1975 Apr 24;292(17):927–927. doi: 10.1056/NEJM197504242921721. [DOI] [PubMed] [Google Scholar]
- Alter M., Hoenig E., Pratzon G. Creutzfeldt-Jakob disease: possible association with eating brains. N Engl J Med. 1977 Apr 7;296(14):820–821. doi: 10.1056/nejm197704072961420. [DOI] [PubMed] [Google Scholar]
- Bell J. F. Creutzfeldt-Jakob disease and sheep brain (cont.) N Engl J Med. 1977 Jun 16;296(24):1415–1415. doi: 10.1056/NEJM197706162962424. [DOI] [PubMed] [Google Scholar]
- Bernoulli C., Siegfried J., Baumgartner G., Regli F., Rabinowicz T., Gajdusek D. C., Gibbs C. J., Jr Danger of accidental person-to-person transmission of Creutzfeldt-Jakob disease by surgery. Lancet. 1977 Feb 26;1(8009):478–479. doi: 10.1016/s0140-6736(77)91958-4. [DOI] [PubMed] [Google Scholar]
- Bobowick A. R., Brody J. A., Matthews M. R., Roos R., Gajdusek D. C. Creutzfeldt-Jakob disease: a case-control study. Am J Epidemiol. 1973 Nov;98(5):381–394. doi: 10.1093/oxfordjournals.aje.a121567. [DOI] [PubMed] [Google Scholar]
- Brotherston J. G., Renwick C. C., Stamp J. T., Zlotnik I., Pattison I. H. Spread and scrapie by contact to goats and sheep. J Comp Pathol. 1968 Jan;78(1):9–17. doi: 10.1016/0021-9975(68)90107-2. [DOI] [PubMed] [Google Scholar]
- Brownell B., Oppenheimer D. R., Hughes J. T. The central nervous system in motor neurone disease. J Neurol Neurosurg Psychiatry. 1970 Jun;33(3):338–357. doi: 10.1136/jnnp.33.3.338. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Duffy P., Wolf J., Collins G., DeVoe A. G., Streeten B., Cowen D. Letter: Possible person-to-person transmission of Creutzfeldt-Jakob disease. N Engl J Med. 1974 Mar 21;290(12):692–693. [PubMed] [Google Scholar]
- Gajdusek D. C., Gibbs C. J., Jr Letter: Survival of Creutzfeldt-Jakob-disease virus in formol-fixed brain tissue. N Engl J Med. 1976 Mar 4;294(10):553–553. doi: 10.1056/nejm197603042941015. [DOI] [PubMed] [Google Scholar]
- Gajdusek D. C., Gibbs C. J., Jr Transmission of kuru from man to rhesus monkey (Macaca mulatta) 8 and one-half years after inoculation. Nature. 1972 Dec 8;240(5380):351–351. doi: 10.1038/240351a0. [DOI] [PubMed] [Google Scholar]
- Garzuly F., Jellinger K., Pilz P. Subakute spongiöse Encephalopthie (Jakob-Creutzfeldt-Syndrom). Klinisch-morphologische Analyse von 9 Fällen. Arch Psychiatr Nervenkr (1970) 1971;214(3):207–227. doi: 10.1007/BF00342625. [DOI] [PubMed] [Google Scholar]
- Gibbs C. J., Jr, Gajdusek D. C., Asher D. M., Alpers M. P., Beck E., Daniel P. M., Matthews W. B. Creutzfeldt-Jakob disease (spongiform encephalopathy): transmission to the chimpanzee. Science. 1968 Jul 26;161(3839):388–389. doi: 10.1126/science.161.3839.388. [DOI] [PubMed] [Google Scholar]
- Herzberg L., Herzberg B. N., Gibbs C. J., Jr, Sullivan W., Amyx H., Gajdusek D. C. Letter: Creutzfeldt-Jakob disease: hypothesis for high incidence in Libyan Jews in Israel. Science. 1974 Nov 29;186(4166):848–848. doi: 10.1126/science.186.4166.848. [DOI] [PubMed] [Google Scholar]
- Manuelidis E. E., Angelo J. N., Gorgacz E. J., Kim J. H., Manuelidis L. Experimental creutzfeldt-jakob disease transmitted via the eye with infected cornea. N Engl J Med. 1977 Jun 9;296(23):1334–1336. doi: 10.1056/NEJM197706092962308. [DOI] [PubMed] [Google Scholar]
- Manuelidis E. E. Transmission of Creutzfeldt-Jakob disease from man to the guinea pig. Science. 1975 Nov 7;190(4214):571–572. [PubMed] [Google Scholar]
- Marsh R. F., Burger D., Eckroade R., Zu Rhein G. M., Hanson R. P. A preliminary report on the experimental host range of the transmissible mink encephalopathy agent. J Infect Dis. 1969 Dec;120(6):713–719. doi: 10.1093/infdis/120.6.713. [DOI] [PubMed] [Google Scholar]
- Matthews W. B. Epidemiology of Creutzfeldt-Jakob disease in England and Wales. J Neurol Neurosurg Psychiatry. 1975 Mar;38(3):210–213. doi: 10.1136/jnnp.38.3.210. [DOI] [PMC free article] [PubMed] [Google Scholar]
- NEVIN S., McMENEMEY W. H., BEHRMAN S., JONES D. P. Subacute spongiform encephalopathy--a subacute form of encephalopathy attributable to vascular dysfunction (spongiform cerebral atrophy). Brain. 1960 Dec;83:519–564. doi: 10.1093/brain/83.4.519. [DOI] [PubMed] [Google Scholar]
- Roos R., Gajdusek D. C., Gibbs C. J., Jr The clinical characteristics of transmissible Creutzfeldt-Jakob disease. Brain. 1973;96(1):1–20. doi: 10.1093/brain/96.1.1. [DOI] [PubMed] [Google Scholar]
- Traub R. D., Gajdusek D. C., Gibbs C. J. Letter: Precautions in autopsies on Creutzfeldt-Jakob disease. Am J Clin Pathol. 1975 Aug;64(2):287–287. doi: 10.1093/ajcp/64.2.287. [DOI] [PubMed] [Google Scholar]