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. 1978 Aug;54(634):566–570. doi: 10.1136/pgmj.54.634.566

Cyclical release of vasoactive intestinal polypeptide (VIP) from a pancreatic islet cell apudoma.

B L Devine, H A Carmichael, R I Russell, S N Joffe
PMCID: PMC2425268  PMID: 215990

Abstract

A patient is described who presented with the classical symptomatology and profound electrolyte disturbance of the Verner-Morrison syndrome due to a pancreatic apudoma secreting vasoactive intestinal polypeptide (VIP). Diagnosis was confirmed by plasma VIP as measured by a radio-immunoassay technique now available. It is suggested that the cyclical nature of the symptoms in this case was due to cyclical release of VIP from the tumour in response to an unknown stimulus. Perfusion studies confirmed the excess secretory state of water, sodium and chloride in the small intestine. Symptoms were completely abolished by surgery and the progress is being monitored by means of serial plasma VIP estimations to detect any early recurrence of metastatic disease.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barbezat G. O., Grossman M. I. Intestinal secretion: stimulation by peptides. Science. 1971 Oct 22;174(4007):422–424. doi: 10.1126/science.174.4007.422. [DOI] [PubMed] [Google Scholar]
  2. Bloom S. R., Polak J. M., Pearse A. G. Vasoactive intestinal peptide and watery-diarrhoea syndrome. Lancet. 1973 Jul 7;2(7819):14–16. doi: 10.1016/s0140-6736(73)91947-8. [DOI] [PubMed] [Google Scholar]
  3. Bodanszky M., Klausner Y. S., Said S. I. Biological activities of synthetic peptides corresponding to fragments of and to the entire sequence of the vasoactive intestinal peptide. Proc Natl Acad Sci U S A. 1973 Feb;70(2):382–384. doi: 10.1073/pnas.70.2.382. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Kahn C. R., Levy A. G., Gardner J. D., Miller J. V., Gorden P., Schein P. S. Pancreatic cholera: benefical effects of treatment with streptozotocin. N Engl J Med. 1975 May 1;292(18):941–945. doi: 10.1056/NEJM197505012921803. [DOI] [PubMed] [Google Scholar]
  5. Russell R. I., Allan J. G., Gerskowitch V. P., Cochran K. M. The effect of conjugated and unconjugated bile acids on water and electrolyte absorption in the human jejunum. Clin Sci Mol Med. 1973 Sep;45(3):301–311. doi: 10.1042/cs0450301. [DOI] [PubMed] [Google Scholar]
  6. Said S. I., Faloona G. R. Elevated plasma and tissue levels of vasoactive intestinal polypeptide in the watery-diarrhea syndrome due to pancreatic, bronchogenic and other tumors. N Engl J Med. 1975 Jul 24;293(4):155–160. doi: 10.1056/NEJM197507242930401. [DOI] [PubMed] [Google Scholar]
  7. Said S. I., Mutt V. Polypeptide with broad biological activity: isolation from small intestine. Science. 1970 Sep 18;169(3951):1217–1218. doi: 10.1126/science.169.3951.1217. [DOI] [PubMed] [Google Scholar]
  8. Schwartz C. J., Kimberg D. V., Sheerin H. E., Field M., Said S. I. Vasoactive intestinal peptide stimulation of adenylate cyclase and active electrolyte secretion in intestinal mucosa. J Clin Invest. 1974 Sep;54(3):536–544. doi: 10.1172/JCI107790. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. VERNER J. V., MORRISON A. B. Islet cell tumor and a syndrome of refractory watery diarrhea and hypokalemia. Am J Med. 1958 Sep;25(3):374–380. doi: 10.1016/0002-9343(58)90075-5. [DOI] [PubMed] [Google Scholar]

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