Skip to main content
PMC home page
Postgraduate Medical Journal logoLink to Postgraduate Medical Journal
. 1979 Feb;55(640):98–104. doi: 10.1136/pgmj.55.640.98

Antigenic memory to influenza A viruses in man determined by monovalent vaccines.

W M Marine, J E Thomas
PMCID: PMC2425381  PMID: 461278

Abstract

This study was conducted to test the limits of the doctrine of 'original antigenic sin' in influenza A. The design included use of zonal purified 1000 CCA (chick cell agglutinating) units monovalent vaccines consisting of H0N1, H1N1, H2N2 and H3N2. Age cohorts with different primary influenza A infections were established for the 687 volunteers. The vaccines administered to each age cohort were selected to test the responsiveness of original antigenic sin antibody to homologous and heterologous challenge. Anamnestic responses were demonstrated with Hsw1n1,H0N1, and H1N1 and with H2N2 and H3N2 but not between the groups. The synthesis of these findings is that there are 2 original antigenic sins - 2 families of influenza A viruses.

Full text

PDF
98

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. DAVENPORT F. M., HENNESSY A. V. A serologic recapitulation of past experiences with influenza A; antibody response to monovalent vaccine. J Exp Med. 1956 Jul 1;104(1):85–97. doi: 10.1084/jem.104.1.85. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. DAVENPORT F. M., HENNESSY A. V. The clinical epidemiology of Asian influenza. Ann Intern Med. 1958 Sep;49(3):493–501. doi: 10.7326/0003-4819-49-3-493. [DOI] [PubMed] [Google Scholar]
  3. Dowdle W. R., Marine W. M., Coleman M., Knez V. Haemagglutinin relationships of Hong Kong(H3) and Asian(H2) influenza strains delineated by antigen-specific recombinants. J Gen Virol. 1972 Aug;16(2):127–134. doi: 10.1099/0022-1317-16-2-127. [DOI] [PubMed] [Google Scholar]
  4. Dowdle W. R., Millar J. D. Swine influenza: lessons learned. Med Clin North Am. 1978 Sep;62(5):1047–1057. doi: 10.1016/s0025-7125(16)31754-0. [DOI] [PubMed] [Google Scholar]
  5. FRANCIS T., Jr, DAVENPORT F. M., HENNESSY A. V. A serological recapitulation of human infection with different strains of influenza virus. Trans Assoc Am Physicians. 1953;66:231–239. [PubMed] [Google Scholar]
  6. FRANCIS T., Jr Influenza: the new acquayantance. Ann Intern Med. 1953 Aug;39(2):203–221. doi: 10.7326/0003-4819-39-2-203. [DOI] [PubMed] [Google Scholar]
  7. FRANCIS T., Jr The current status of the control of influenza. Ann Intern Med. 1955 Sep;43(3):534–538. doi: 10.7326/0003-4819-43-3-534. [DOI] [PubMed] [Google Scholar]
  8. HILLEMAN M. R., FLATLEY F. J., ANDERSON S. A., LUECKING M. L., LEVINSON D. J. Antibody response in volunteers to Asian influenza vaccine. J Am Med Assoc. 1958 Mar 8;166(10):1134–1140. doi: 10.1001/jama.1958.02990100022005. [DOI] [PubMed] [Google Scholar]
  9. JENSEN K. E., DAVENPORT F. M., HENNESSY A. V., FRANCIS T., Jr Characterization of influenza antibodies by serum absorption. J Exp Med. 1956 Aug 1;104(2):199–209. doi: 10.1084/jem.104.2.199. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. MULDER J., MASUREL N. Pre-epidemic antibody against 1957 strain of Asiatic influenza in serum of older people living in the Netherlands. Lancet. 1958 Apr 19;1(7025):810–814. doi: 10.1016/s0140-6736(58)91738-0. [DOI] [PubMed] [Google Scholar]
  11. Marine W. M., Thomas J. E. Age-related response to 1000 CCA unit zonally purified, inactivated influenza vaccines in volunteers in the U.S.A. Postgrad Med J. 1973 Mar;49(569):164–168. doi: 10.1136/pgmj.49.569.164. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Marine W. M., Workman W. M. Hong Kong influenza immunologic recapitulation. Am J Epidemiol. 1969 Nov;90(5):406–415. doi: 10.1093/oxfordjournals.aje.a121086. [DOI] [PubMed] [Google Scholar]
  13. Marine W. M., Workman W. M., Webster R. G. Immunological interrelationships of Hong Kong, Asian and equi-2 influenza viruses in man. Bull World Health Organ. 1969;41(3):475–482. [PMC free article] [PubMed] [Google Scholar]
  14. Masurel N., Marine W. M. Recycling of Asian and Hong Kong influenza A virus hemagglutinins in man. Am J Epidemiol. 1973 Jan;97(1):44–49. doi: 10.1093/oxfordjournals.aje.a121483. [DOI] [PubMed] [Google Scholar]
  15. Masurel N. Prevention of influenza A by immunization. Maandschr Kindergeneeskd. 1968 Nov;36(7):207–211. [PubMed] [Google Scholar]
  16. Masurel N. Relation between Hong Kong virus and former human A2 isolates and the A-EQU12 virus in human sera collected before 1957. Lancet. 1969 May 3;1(7601):907–910. doi: 10.1016/s0140-6736(69)92544-6. [DOI] [PubMed] [Google Scholar]
  17. Morita M., Suto T., Ishida N. Antigenic memory in man in response to sequential infections with influenza A viruses. J Infect Dis. 1972 Jul;126(1):61–68. doi: 10.1093/infdis/126.1.61. [DOI] [PubMed] [Google Scholar]
  18. Noble G. R., Kaye H. S., Kendal A. P., Dowdle W. R. Age-related heterologous antibody responses to influenza virus vaccination. J Infect Dis. 1977 Dec;136 (Suppl):S686–S692. doi: 10.1093/infdis/136.supplement_3.s686. [DOI] [PubMed] [Google Scholar]
  19. SALK J. E. An interpretation of the significance of influenza virus variation for the development of an effective vaccine. Bull N Y Acad Med. 1952 Nov;28(11):748–765. [PMC free article] [PubMed] [Google Scholar]
  20. Schoenbaum S. C., Coleman M. T., Dowdle W. R., Mostow S. R. Epidemiology of influenza in the elderly: evidence of virus recycling. Am J Epidemiol. 1976 Feb;103(2):166–173. doi: 10.1093/oxfordjournals.aje.a112214. [DOI] [PubMed] [Google Scholar]
  21. Shope R. E. THE INCIDENCE OF NEUTRALIZING ANTIBODIES FOR SWINE INFLUENZA VIRUS IN THE SERA OF HUMAN BEINGS OF DIFFERENT AGES. J Exp Med. 1936 Apr 30;63(5):669–684. doi: 10.1084/jem.63.5.669. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Stuart-Harris C. H. Virus of the 1918 influenza pandemic. Nature. 1970 Feb 28;225(5235):850–851. doi: 10.1038/225850a0. [DOI] [PubMed] [Google Scholar]

Articles from Postgraduate Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES