Abstract
About 50 cases of leptospirosis are diagnosed each year in the United Kingdom, with an overall mortality of 5%. Renal failure, in association with jaundice, is commonly held responsible for this figure. Over a period of 18 years, 6 cases of leptospirosis complicated by renal failure were treated at the Royal Air Force Renal Unit; there were 4 survivors. The 2 deaths occurred before the unit policy of daily haemodialysis and total parenteral nutrition, and were both from haemorrhagic complications. The authors believe that patients with leptospirosis and progressive renal impairment should be managed in renal units experienced in the management of the hypercatabolic patient, and that this should improve their prognosis.
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Selected References
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- Barrett-Connor E., Child C. M., Carter M. J. Renal failure in leptospirosis. South Med J. 1970 May;63(5):580–583. doi: 10.1097/00007611-197005000-00022. [DOI] [PubMed] [Google Scholar]
- DEBRITO T., FREYMUELLER E., PENNA D. O., SANTOS H. S., DEALMEIDA S. S., AYROZAGALVAO P. A., PEREIRA V. G. ELECTRON MICROSCOPY OF THE BIOPSIED KIDNEY IN HUMAN LEPTOSPIROSIS. Am J Trop Med Hyg. 1965 May;14:397–403. doi: 10.4269/ajtmh.1965.14.397. [DOI] [PubMed] [Google Scholar]
- Flynn C. T. Peritoneal dialysis in hypercatabolic acute renal failure. Lancet. 1967 Jun 17;1(7503):1331–1332. doi: 10.1016/s0140-6736(67)91634-0. [DOI] [PubMed] [Google Scholar]
- Heath C. W., Jr, Alexander A. D., Galton M. M. Leptospirosis in the United States. N Engl J Med. 1965 Oct 14;273(16):857–contd. doi: 10.1056/NEJM196510142731606. [DOI] [PubMed] [Google Scholar]
- Marshall R. B. Ultrastructural changes in renal tubules of sheep following experimental infection with Leptospira interrogans serotype pomona. J Med Microbiol. 1974 Nov;7(4):505–508. doi: 10.1099/00222615-7-4-505. [DOI] [PubMed] [Google Scholar]
- PARSONS F. M., HOBSON S. M., BLAGG C. R., McCRACKEN B. H. Optimum time for dialysis in acute reversible renal failure. Description and value of an improved dialyser with large surface area. Lancet. 1961 Jan 21;1(7169):129–134. doi: 10.1016/s0140-6736(61)91309-5. [DOI] [PubMed] [Google Scholar]
- Rainford D. J. The immediate care of acute renal failure. Anaesthesia. 1977 Mar;32(3):277–281. doi: 10.1111/j.1365-2044.1977.tb11610.x. [DOI] [PubMed] [Google Scholar]
- Simpson B., Cook A. T., Dimond A. H., Brown M., Thin R. N. Renal function after leptospirosis. Br Med J. 1967 Aug 19;3(5563):472–473. doi: 10.1136/bmj.3.5563.472. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sitprija V., Evans H. The kidney in human leptospirosis. Am J Med. 1970 Dec;49(6):780–788. doi: 10.1016/s0002-9343(70)80059-6. [DOI] [PubMed] [Google Scholar]
- Sitprija V. Renal involvement in human leptospirosis. Br Med J. 1968 Jun 15;2(5606):656–658. doi: 10.1136/bmj.2.5606.656. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Turner L. H. Leptospirosis. I. Trans R Soc Trop Med Hyg. 1967;61(6):842–855. doi: 10.1016/0035-9203(67)90045-4. [DOI] [PubMed] [Google Scholar]
- de Brito T., Penna D. O., Pereira V. C., Hoshino S. Kidney biopsies in human leptospirosis: a biochemical and electron microscopy study. Virchows Arch Pathol Anat Physiol Klin Med. 1967;343(2):124–135. doi: 10.1007/BF01429733. [DOI] [PubMed] [Google Scholar]
