Abstract
Malabsorption of prednisolone administered as enteric coated tablets was suspected following therapeutic failure in an asthmatic. This was investigated by cortisol estimation and a Synacthen test and substantiated by the demonstration of abnormally low absorption of prednisolone from these tablets which nevertheless were normally absorbed by a volunteer. The absorption of prednisolone from conventional tablets in this patient was normal.
Full text
PDF

Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Morrison P. J., Bradbrook I. D., Rogers H. J. Plasma prednisolone levels from enteric and non-enteric coated tablets estimated by an original technique. Br J Clin Pharmacol. 1977 Oct;4(5):597–603. doi: 10.1111/j.1365-2125.1977.tb00792.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Nimmo W. S. Drugs, diseases and altered gastric emptying. Clin Pharmacokinet. 1976;1(3):189–203. doi: 10.2165/00003088-197601030-00002. [DOI] [PubMed] [Google Scholar]
- PERKINS F. T., YETTS R., GAISFORD W. Response of infants to a third dose of poliomyelitis vaccine given 10 to 12 months after primary immunization. Br Med J. 1959 Mar 14;1(5123):680–682. doi: 10.1136/bmj.1.5123.680. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Parsons R. L. Drug absorption in gastrointestinal disease with particular reference to malabsorption syndromes. Clin Pharmacokinet. 1977 Jan-Feb;2(1):45–60. doi: 10.2165/00003088-197702010-00004. [DOI] [PubMed] [Google Scholar]
- Shenfield G. M., Paterson J. W., Costello J. F., Ijaduola O. The effect of prednisone treatment on the half-life of intravenous hydrocortisone. Br J Clin Pharmacol. 1974 Jun;1(3):237–240. doi: 10.1111/j.1365-2125.1974.tb00243.x. [DOI] [PMC free article] [PubMed] [Google Scholar]