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. 1980 May;56(655):363–365. doi: 10.1136/pgmj.56.655.363

Severe barbiturate and paracetamol overdose: the simultaneous removal of both poisons by haemoperfusion.

M Helliwell
PMCID: PMC2425606  PMID: 7443601

Abstract

Charcoal haemoperfusion was successful in the treatment of severe butobarbitone poisoning complicated by resistant hypotension. At the same time the rapid removal of paracetamol may have lessened the severity of the subsequent hepatic injury. The mechanism and management of shock associated with barbiturate poisoning, and the possible application of haemoperfusion in paracetamol poisoning are discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Crome P., Vale J. A., Volans G. N., Widdop B., Goulding R. Oral methionine in the treatment of severe paracetamol (Acetaminophen) overdose. Lancet. 1976 Oct 16;2(7990):829–830. doi: 10.1016/s0140-6736(76)91211-3. [DOI] [PubMed] [Google Scholar]
  2. Crome P., Volans G. N., Vale J. A., Widdop B., Goulding R. The use of methionine for acute paracetamol poisoning. J Int Med Res. 1976;4(4 Suppl):105–111. doi: 10.1177/14732300760040S419. [DOI] [PubMed] [Google Scholar]
  3. Douglas A. P., Hamlyn A. N., James O. Controlled trial of cysteamine in treatment of acute paracetamol (acetaminophen) poisoning. Lancet. 1976 Jan 17;1(7951):111–115. doi: 10.1016/s0140-6736(76)93154-8. [DOI] [PubMed] [Google Scholar]
  4. Gazzard B. G., Widdop B., Davis M., Hughes R. D., Goulding R., Williams R. Early prediction of the outcome of a paracetamol overdose based on an analysis of 163 patients. Postgrad Med J. 1977 May;53(619):243–247. doi: 10.1136/pgmj.53.619.243. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Gazzard B. G., Willison R. A., Weston M. J., Thompson R. P., Williams R. Charcoal haemoperfusion for paracetamol overdose. Br J Clin Pharmacol. 1974 Jun;1(3):271–275. doi: 10.1111/j.1365-2125.1974.tb00249.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Goldberg L. I. Recent advances in the pharmacology of catecholamines. Intensive Care Med. 1977 Dec;3(4):233–236. doi: 10.1007/BF01641112. [DOI] [PubMed] [Google Scholar]
  7. Prescott L. F., Park J., Ballantyne A., Adriaenssens P., Proudfoot A. T. Treatment of paracetamol (acetaminophen) poisoning with N-acetylcysteine. Lancet. 1977 Aug 27;2(8035):432–434. doi: 10.1016/s0140-6736(77)90612-2. [DOI] [PubMed] [Google Scholar]
  8. Prescott L. F., Roscoe P., Wright N., Brown S. S. Plasma-paracetamol half-life and hepatic necrosis in patients with paracetamol overdosage. Lancet. 1971 Mar 13;1(7698):519–522. doi: 10.1016/s0140-6736(71)91125-1. [DOI] [PubMed] [Google Scholar]
  9. SHUBIN H., WEIL M. H. THE MECHANISM OF SHOCK FOLLOWING SUICIDAL DOSES OF BARBITURATES, NARCOTICS AND TRANQUILIZER DRUGS, WITH OBSERVATIONS ON THE EFFECTS OF TREATMENT. Am J Med. 1965 Jun;38:853–863. doi: 10.1016/0002-9343(65)90004-5. [DOI] [PubMed] [Google Scholar]
  10. Shubin H., Weil M. H. Shock associated with barbiturate intoxication. JAMA. 1971 Jan 11;215(2):263–268. [PubMed] [Google Scholar]
  11. Vale J. A., Rees A. J., Widdop B., Goulding R. Use of charcoal haemoperfusion in the management of severely poisoned patients. Br Med J. 1975 Jan 4;1(5948):5–9. doi: 10.1136/bmj.1.5948.5. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Widdop B., Medd R. K., Braithwaite R. A., Rees A. J., Goulding R. Experimental drug intoxication: treatment with charcoal haemoperfusion. Arch Toxicol. 1975 Sep 5;34(1):27–36. doi: 10.1007/BF00353336. [DOI] [PubMed] [Google Scholar]
  13. Wrights N., Prescott L. F. Potentiation by previous drug therapy of hepatotoxicity following paracetamol overdosage. Scott Med J. 1973 Mar;18(2):56–58. doi: 10.1177/003693307301800205. [DOI] [PubMed] [Google Scholar]

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