Abstract
Mixtures of mycolytic enzymes from various sources release protoplasts from living fungal tissue under suitable conditions. Such enzyme mixtures obtained from Coprinus comatus (mycolase I), Physarum polycephalum (mycolase II) and Lycoperdon pyriforme (mycolase III) are of low toxicity in mammals when given parenterally and are able to cure experimental systemic fungal infections in mice when administered alone or in conjunction with normally ineffective levels of conventional antimycotic drugs such as amphotericin B. The effect is believed to be due to enzymic degradation of the fungal cell wall either killing the fungus directly or enhancing activity of existing antifungal agents by increasing access to the cell interior.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Ajello L. The medical mycological iceberg. HSMHA Health Rep. 1971 May;86(5):437–448. [PMC free article] [PubMed] [Google Scholar]
- Bartinicki-Garcia S., Lippman E. Liberation of protoplasts from the mycelium of Phytophthora. J Gen Microbiol. 1966 Mar;42(3):411–416. doi: 10.1099/00221287-42-3-411. [DOI] [PubMed] [Google Scholar]
- Bartnicki-Garcia S. Cell wall chemistry, morphogenesis, and taxonomy of fungi. Annu Rev Microbiol. 1968;22:87–108. doi: 10.1146/annurev.mi.22.100168.000511. [DOI] [PubMed] [Google Scholar]
- Bodey G. P. Fungal infections in the cancer patient. S Afr Med J. 1977 Dec 10;52(25):1009–1015. [PubMed] [Google Scholar]
- Davies D. A., Pope A. M. Mycolase, a new kind of systemic antimycotic. Nature. 1978 May 18;273(5659):235–236. doi: 10.1038/273235a0. [DOI] [PubMed] [Google Scholar]
- Endo A., Kakiki K., Misato T. Mechanism of action of the antifugal agent polyoxin D. J Bacteriol. 1970 Oct;104(1):189–196. doi: 10.1128/jb.104.1.189-196.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gale E. F., Johnson A. M., Kerridge D., Koh T. Y. Factors affecting the changes in amphotericin sensitivity of Candida albicans during growth. J Gen Microbiol. 1975 Mar;87(1):20–36. doi: 10.1099/00221287-87-1-20. [DOI] [PubMed] [Google Scholar]
- MIURA O. Utilization of chitinase in treatment of dermatomycosis. I. Influence of Bacilli chitinovori on the culture of dermatophytes. Tohoku J Exp Med. 1954 Apr 25;59(4):403–406. doi: 10.1620/tjem.59.403. [DOI] [PubMed] [Google Scholar]
- Mason J. W., Stinson E. B., Hunt S. A., Schroeder J. S., Rider A. K. Infections after cardiac transplantation: relation to rejection therapy. Ann Intern Med. 1976 Jul;85(1):69–72. doi: 10.7326/0003-4819-85-1-69. [DOI] [PubMed] [Google Scholar]
- Peto R., Pike M. C. Conservatism of the approximation sigma (O-E)2-E in the logrank test for survival data or tumor incidence data. Biometrics. 1973 Sep;29(3):579–584. [PubMed] [Google Scholar]
- Utz J. P. The current status of chemotherapeutic agents for the systemic mycoses. Contrib Microbiol Immunol. 1977;4:124–135. [PubMed] [Google Scholar]