Skip to main content
NCBI home page
Postgraduate Medical Journal logoLink to Postgraduate Medical Journal
. 1979 Sep;55(647):653–656. doi: 10.1136/pgmj.55.647.653

The polyene macrolide antibiotics.

D Kerridge
PMCID: PMC2425654  PMID: 392481

Abstract

The mode of action of the polyene antibiotics is reviewed together with the effect of genetic and environmental factors on sensitive organisms. The future prospects of polyenes in the treatment of systemic mycoses are considered.

Full text

PDF
653

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Andreoli T. E. On the anatomy of amphotericin B-cholesterol pores in lipid bilayer membranes. Kidney Int. 1973 Nov;4(5):337–345. doi: 10.1038/ki.1973.126. [DOI] [PubMed] [Google Scholar]
  2. Archer D. B., Gale E. F. Antagonism by sterols of the action of amphotericin and filipin on the release of potassium ions from Candida albicans and Mycoplasma mycoides subsp. capri. J Gen Microbiol. 1975 Sep;90(1):187–190. doi: 10.1099/00221287-90-1-187. [DOI] [PubMed] [Google Scholar]
  3. Bittman R., Fischkoff S. A. Fluorescence studies of the binding of the polyene antibiotics filipin 3, amphotericin B, nystatin, and lagosin to cholesterol. Proc Natl Acad Sci U S A. 1972 Dec;69(12):3795–3799. doi: 10.1073/pnas.69.12.3795. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Cartwright R. Y. Antifungal drugs. J Antimicrob Chemother. 1975 Jun;1(2):141–162. doi: 10.1093/jac/1.2.141. [DOI] [PubMed] [Google Scholar]
  5. Cassone A., Kerridge D., Gale E. F. Ultrastructural changes in the cell wall of Candida albicans following cessation of growth and their possible relationship to the development of polyene resistance. J Gen Microbiol. 1979 Feb;110(2):339–349. doi: 10.1099/00221287-110-2-339. [DOI] [PubMed] [Google Scholar]
  6. Chen W. C., Chou D. L., Feingold D. S. Dissociation between ion permeability and the lethal action of polyene antibiotics on Candida albicans. Antimicrob Agents Chemother. 1978 Jun;13(6):914–917. doi: 10.1128/aac.13.6.914. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Chen W. C., Sud I. J., Chou D. L., Feingold D. S. Selective toxicity of the polyene antibiotics and their methyl ester derivatives. Biochem Biophys Res Commun. 1977 Jan 24;74(2):480–487. doi: 10.1016/0006-291x(77)90329-1. [DOI] [PubMed] [Google Scholar]
  8. Gale E. F., Johnson A. M., Kerridge D., Koh T. Y. Factors affecting the changes in amphotericin sensitivity of Candida albicans during growth. J Gen Microbiol. 1975 Mar;87(1):20–36. doi: 10.1099/00221287-87-1-20. [DOI] [PubMed] [Google Scholar]
  9. Gale E. F., Johnson A. M., Kerridge D., Miles E. A. Phenotypic resistance to amphotericin B in Candida albicans: the role of reduction. J Gen Microbiol. 1978 Dec;109(2):191–204. doi: 10.1099/00221287-109-2-191. [DOI] [PubMed] [Google Scholar]
  10. Gale E. F., Johnson A. M., Kerridge D. The effect of aeration and metabolic inhibitors on resistance to amphotericin in starved cultures of Candida albicans. J Gen Microbiol. 1977 Mar;99(1):77–84. doi: 10.1099/00221287-99-1-77. [DOI] [PubMed] [Google Scholar]
  11. Gale E. F. Perspectives in chemotherapy. Br Med J. 1973 Oct 6;4(5883):33–38. doi: 10.1136/bmj.4.5883.33. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Gale E. F. The release of potassium ions from Candida albicans in the presence of polyene antibiotics. J Gen Microbiol. 1974 Feb;80(2):451–465. doi: 10.1099/00221287-80-2-451. [DOI] [PubMed] [Google Scholar]
  13. Hamilton-Miller J. M. A comparative in vitro study of amphotericin B 1 clotrimazole and 5-fluorocytosine against clinically isolated yeasts. Sabouraudia. 1972 Nov;10(3):276–283. [PubMed] [Google Scholar]
  14. Hamilton-Miller J. M. Chemistry and biology of the polyene macrolide antibiotics. Bacteriol Rev. 1973 Sep;37(3):166–196. [PMC free article] [PubMed] [Google Scholar]
  15. Hammond S. M., Lambert P. A., Kliger B. N. The mode of action of polyene antibiotics; induced potassium leakage in Candida albicans. J Gen Microbiol. 1974 Apr;81(2):325–330. doi: 10.1099/00221287-81-2-325. [DOI] [PubMed] [Google Scholar]
  16. Holz R. W. The effects of the polyene antibiotics nystatin and amphotericin B on thin lipid membranes. Ann N Y Acad Sci. 1974 May 10;235(0):469–479. doi: 10.1111/j.1749-6632.1974.tb43284.x. [DOI] [PubMed] [Google Scholar]
  17. HsuChen C. C., Feingold D. S. Polyene antibiotic action on lecithin liposomes: effect of cholesterol and fatty acyl chains. Biochem Biophys Res Commun. 1973 Apr 16;51(4):972–978. doi: 10.1016/0006-291x(73)90022-3. [DOI] [PubMed] [Google Scholar]
  18. HsuChen C. C., Feingold D. S. Two types of resistance to polyene antibiotics in Candida albicans. Nature. 1974 Oct 18;251(5476):656–659. doi: 10.1038/251656a0. [DOI] [PubMed] [Google Scholar]
  19. Johnson B., White R. J., Williamson G. M. Factors influencing the susceptibility of Candida albicans to the polyenoic antibiotics nystatin and amphotericin B. J Gen Microbiol. 1978 Feb;104(2):325–333. doi: 10.1099/00221287-104-2-325. [DOI] [PubMed] [Google Scholar]
  20. Kerridge D., Koh T. Y., Johnson A. M. The interaction of amphotericin B methyl ester with protoplasts of Candida albicans. J Gen Microbiol. 1976 Sep;96(1):117–123. doi: 10.1099/00221287-96-1-117. [DOI] [PubMed] [Google Scholar]
  21. Kobayashi G. S., Medoff G. Antifungal agents: recent developments. Annu Rev Microbiol. 1977;31:291–308. doi: 10.1146/annurev.mi.31.100177.001451. [DOI] [PubMed] [Google Scholar]
  22. Koh T. Y., Marriott M. S., Taylor J., Gale E. F. Growth characteristics and polyene sensitivity of a fatty acid auxotroph of Candida albicans. J Gen Microbiol. 1977 Sep;102(1):105–110. doi: 10.1099/00221287-102-1-105. [DOI] [PubMed] [Google Scholar]
  23. Kumar B. V., Medoff G., Kobayashi G., Schlessinger D. Uptake of Escherichia coli DNA into HeLa cells enhanced by amphotericin B. Nature. 1974 Jul 26;250(464):323–325. doi: 10.1038/250323a0. [DOI] [PubMed] [Google Scholar]
  24. Liras P., Lampen J. O. Protection by K+ and Mg2+ of growth and macromolecule synthesis in candicidin-treated yeast. Biochim Biophys Acta. 1974 Dec 6;374(2):159–163. doi: 10.1016/0005-2787(74)90359-1. [DOI] [PubMed] [Google Scholar]
  25. Marty A., Finkelstein A. Pores formed in lipid bilayer membranes by nystatin, Differences in its one-sided and two-sided action. J Gen Physiol. 1975 Apr;65(4):515–526. doi: 10.1085/jgp.65.4.515. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Mechlinski W., Schaffner C. P. Polyene macrolide derivatives. I. N-acylation and esterification reactions with amphotericin B. J Antibiot (Tokyo) 1972 Apr;25(4):256–258. [PubMed] [Google Scholar]
  27. Palacios J., Serrano R. Proton permeability induced by polyene antibiotics. A plausible mechanism for their inhibition of maltose fermentation in yeast. FEBS Lett. 1978 Jul 15;91(2):198–201. doi: 10.1016/0014-5793(78)81171-5. [DOI] [PubMed] [Google Scholar]
  28. Peña A. Studies on the mechanism of K+ transport in yeast. Arch Biochem Biophys. 1975 Apr;167(2):397–409. doi: 10.1016/0003-9861(75)90480-4. [DOI] [PubMed] [Google Scholar]
  29. Pierce A. M., Pierce H. D., Jr, Unrau A. M., Oehlschlager A. C. Lipid composition and polyene antibiotic resistance of Candida albicans mutants. Can J Biochem. 1978 Feb;56(2):135–142. doi: 10.1139/o78-023. [DOI] [PubMed] [Google Scholar]
  30. Thomas A. H. Analysis and assay of polyene antifungal antibiotics. A review. Analyst. 1976 May;101(1202):321–340. doi: 10.1039/an9760100321. [DOI] [PubMed] [Google Scholar]

Articles from Postgraduate Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES