Abstract
Fungal infections of the central nervous system present a considerable challenge to available chemotherapy and other forms of treatment. The particular difficulties are discussed here, after an account of the fungi involved and their sensitivity to antifungal agents. Cryptococcal, coccidioidal and candidal infections are considered in more detail.
Full text
PDF



Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bindschadler D. D., Bennett J. E. A pharmacologic guide to the clinical use of amphotericin B. J Infect Dis. 1969 Oct;120(4):427–436. doi: 10.1093/infdis/120.4.427. [DOI] [PubMed] [Google Scholar]
- Block E. R., Bennett J. E. Pharmacological studies with 5-fluorocytosine. Antimicrob Agents Chemother. 1972 Jun;1(6):476–482. doi: 10.1128/aac.1.6.476. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Block E. R., Bennett J. E. The combined effect of 5-fluorocytosine and amphotericin B in the therapy of murine cryptococcosis. Proc Soc Exp Biol Med. 1973 Feb;142(2):476–480. doi: 10.3181/00379727-142-37049. [DOI] [PubMed] [Google Scholar]
- Deresinski S. C., Lilly R. B., Levine H. B., Galgiani J. N., Stevens D. A. Treatment of fungal meningitis with miconazole. Arch Intern Med. 1977 Sep;137(9):1180–1185. [PubMed] [Google Scholar]
- Diamond R. D., Bennett J. E. A subcutaneous reservoir for intrathecal therapy of fungal meningitis. N Engl J Med. 1973 Jan 25;288(4):186–188. doi: 10.1056/NEJM197301252880405. [DOI] [PubMed] [Google Scholar]
- Fisher J. F., Duma R. J., Markowitz S. M., Shadomy S., Espinel-Ingroff A., Chew W. H. Therapeutic failures with miconazole. Antimicrob Agents Chemother. 1978 Jun;13(6):965–968. doi: 10.1128/aac.13.6.965. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Krick J. A., Remington J. S. Editoral: Treatment of fungal infections. Arch Intern Med. 1975 Feb;135(2):344–346. [PubMed] [Google Scholar]
- Levine H. B., Ringel S. M., Cobb J. M. Therapeutic properties of oral ambruticin (W7783) in experimental pulmonary coccidioidomycosis of mice. Chest. 1978 Feb;73(2):202–206. doi: 10.1378/chest.73.2.202. [DOI] [PubMed] [Google Scholar]
- Medoff G., Comfort M., Kobayashi G. S. Synergistic action of amphotericin B and 5-fluorocytosine against yeast-like organisms. Proc Soc Exp Biol Med. 1971 Nov;138(2):571–574. doi: 10.3181/00379727-138-35943. [DOI] [PubMed] [Google Scholar]
- Medoff G., Kobayashi G. S. Amphotericin B. Old drug, new therapy.?2110. JAMA. 1975 May 12;232(6):619–620. doi: 10.1001/jama.232.6.619. [DOI] [PubMed] [Google Scholar]
- Parker J. C., Jr, McCloskey J. J., Lee R. S. The emergence of candidosis. The dominant postmortem cerebral mycosis. Am J Clin Pathol. 1978 Jul;70(1):31–36. doi: 10.1093/ajcp/70.1.31. [DOI] [PubMed] [Google Scholar]
- Speller D. C., Fakunle F., Cairns S. A., Stephens M. Cryptococcal meningitis complicating systemic lupus erythematosus: two patients treated with flucytosine and amphotericin B. J Clin Pathol. 1977 Mar;30(3):254–261. doi: 10.1136/jcp.30.3.254. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sung J. P., Grendahl J. G., Levine H. B. Intravenous and intrathecal miconazole therapy for systemic mycoses. West J Med. 1977 Jan;126(1):5–13. [PMC free article] [PubMed] [Google Scholar]
- Utz J. P., Garriques I. L., Sande M. A., Warner J. F., Mandell G. L., McGehee R. F., Duma R. J., Shadomy S. Therapy of cryptococcosis with a combination of flucytosine and amphotericin B. J Infect Dis. 1975 Oct;132(4):368–373. doi: 10.1093/infdis/132.4.368. [DOI] [PubMed] [Google Scholar]
- WINN W. A. The diagnosis and treatment of coccidioidomycosis. Ariz Med. 1962 Oct;19:211–217. [PubMed] [Google Scholar]
- Williams T. W., Jr Meningitis: special techniques in treatment. Mod Treat. 1970 May;7(3):606–615. [PubMed] [Google Scholar]