Skip to main content
NCBI home page
Postgraduate Medical Journal logoLink to Postgraduate Medical Journal
. 1979 Oct;55(648):716–720. doi: 10.1136/pgmj.55.648.716

A review of the Zollinger-Ellison syndrome--with particular reference to a patient treated with cimetidine.

R J Wyke, G L Hill, A T Axon
PMCID: PMC2425758  PMID: 537959

Abstract

A case of the Zollinger-Ellison syndrome, presented with watery diarrhoea, malabsorption and multiple duodenal ulcers. Resection of a gastrinoma from the head of the pancreas was ineffective. Cimetidine, administered for more than 30 months produced an immediate and sustained relief of symptoms with a gain in weight of 19 kg and improvement of the biochemical features of malabsorption. Gastric acid secretion has been markedly inhibited and duodenal ulceration healed.

Full text

PDF
716

Images in this article

717Fig. 2
on p.717
718Fig. 3
on p.718

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bianchi Porro G., Dolcini R., Grossi E., Petrillo M., Prada A. Cimetidine in treatment of pancreatic insufficiency. Lancet. 1977 Oct 22;2(8043):878–879. doi: 10.1016/s0140-6736(77)90818-2. [DOI] [PubMed] [Google Scholar]
  2. Bradley E. L., 3rd, Isaacs J., Hersh T., Davidson E. D., Millikan W. Nutritional consequences of total gastrectomy. Ann Surg. 1975 Oct;182(4):415–429. doi: 10.1097/00000658-197510000-00007. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Burland W. L., Duncan W. A., Hesselbo T., Mills J. G., Sharpe P. C., Haggie S. J., Wyllie J. H. Pharmacological evaluation of cimetidine, a new histamine H2-receptor antagonist, in healthy man. Br J Clin Pharmacol. 1975 Dec;2(6):481–486. doi: 10.1111/j.1365-2125.1975.tb00564.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. ELLISON E. H., WILSON S. D. THE ZOLLINGER-ELLISON SYNDROME: RE-APPRAISAL AND EVALUATION OF 260 REGISTERED CASES. Ann Surg. 1964 Sep;160:512–530. doi: 10.1097/00000658-196409000-00013. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Ellison E. H., Wilson S. D. Ulcerogenic tumor of the pancreas. Prog Clin Cancer. 1967;3:225–244. [PubMed] [Google Scholar]
  6. Friesen S. R., Schimke R. N., Pearse A. G. Genetic aspects of the Z-E syndrome: prospective studies in two kindred; antral gastrin cell hyperplasia. Ann Surg. 1972 Sep;176(3):370–383. doi: 10.1097/00000658-197209000-00013. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Frost F., Rahbek I., Rune S. J., Jensen K. B., Gudmand-Hoyer E., Krag E., Rask-Madsen J., Wulff H. R., Garbol J., Jensen K. G. Cimetidine in patients with gastric ulcer: a multicentre controlled trial. Br Med J. 1977 Sep 24;2(6090):795–797. doi: 10.1136/bmj.2.6090.795. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Gray G. R., Smith I. S., McKenzie I., Crean G. P., Gillespie G. Oral cimetidine in severe duodenal ulceration. A double-blind controlled trial. Lancet. 1977 Jan 1;1(8001):4–7. doi: 10.1016/s0140-6736(77)91650-6. [DOI] [PubMed] [Google Scholar]
  9. Larkworthy W., Davies H. L. Cimetidine in the management of the Zollinger-Ellison syndrome. Postgrad Med J. 1977 Dec;53(626):749–750. doi: 10.1136/pgmj.53.626.749. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. McCarthy D. M., Olinger E. J., May R. J., Long B. W., Gardner J. D. H2-Histamine receptor blocking agents in the Zollinger-Ellison syndrome. Experience in seven cases and implications for long-term therapy. Ann Intern Med. 1977 Dec;87(6):668–675. doi: 10.7326/0003-4819-87-6-668. [DOI] [PubMed] [Google Scholar]
  11. McCarthy D. M. Report on the United States experience with cimetidine in Zollinger-Ellision syndrome and other hypersecretory states. Gastroenterology. 1978 Feb;74(2 Pt 2):453–458. [PubMed] [Google Scholar]
  12. Orchard J. L., Peternel W. W. Cimetidine therapy in Zollinger-Ellison syndrome. JAMA. 1977 May 16;237(20):2221–2221. [PubMed] [Google Scholar]
  13. Pounder R. E., Williams J. G., Milton-Thompson G. J., Misiewicz J. J. Effect of cimetidine on 24-hour intragastric acidity in normal subjects. Gut. 1976 Feb;17(2):133–138. doi: 10.1136/gut.17.2.133. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Regan P. T., Malagelada J. R., DiMagno E. P., Glanzman S. L., Go V. L. Comparative effects of antacids, cimetidine and enteric coating on the therapeutic response to oral enzymes in severe pancreatic insufficiency. N Engl J Med. 1977 Oct 20;297(16):854–858. doi: 10.1056/NEJM197710202971603. [DOI] [PubMed] [Google Scholar]
  15. Sadoff L., Franklin D. Letter: Streptozotocin in the Zollinger-Ellison syndrome. Lancet. 1975 Sep 13;2(7933):504–505. doi: 10.1016/s0140-6736(75)90580-2. [DOI] [PubMed] [Google Scholar]
  16. Shimoda S. S., Rubin C. E. The Zollinger-Ellison syndrome with steatorrhea. I. Anticholinergic treatment followed by total gastrectomy and colonic interposition. Gastroenterology. 1968 Dec;55(6):695–704. [PubMed] [Google Scholar]
  17. Thompson J. C., Reeder D. D., Villar H. V., Fender H. R. Natural history and experience with diagnosis and treatment of the Zollinger-Ellison syndrome. Surg Gynecol Obstet. 1975 May;140(5):721–739. [PubMed] [Google Scholar]
  18. Weber A. M., Roy C. C., Chartrand L., Lepage G., Dufour O. L., Morin C. L., Lasalle R. Relationship between bile acid malabsorption and pancreatic insufficiency in cystic fibrosis. Gut. 1976 Apr;17(4):295–299. doi: 10.1136/gut.17.4.295. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. ZOLLINGER R. M., ELLISON E. H. Primary peptic ulcerations of the jejunum associated with islet cell tumors of the pancreas. Ann Surg. 1955 Oct;142(4):709-23; discussion, 724-8. [PMC free article] [PubMed] [Google Scholar]

Articles from Postgraduate Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES