Abstract
Cimetidine has been shown to stimulate prolactin secretion after a intravenous administration. Cimetidine 200 mg and ranitidine 50 mg was given i.v. in a randomly allocated order to 22 volunteers on consecutive days; these doses can be regarded as equivalent as far as inhibition of gastric acid output is concerned. Plasma prolactin was estimated at regular intervals. The prolactin stimulating effect of cimetidine was confirmed while ranitidine did not influence plasma prolactin levels. Although cimetidine and ranitidine seem to be equally effective in reducing gastric acid output, the effect of the drugs are not the same on their entire spectrum of action since ranitidine does not influence plasma prolactin. It still has to be established in clinical trials which drug is the best choice in clinical medicine.
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Selected References
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- Arakelian M. C., Libertun C. H1 and H2 histamine receptor participation in the brain control of prolactin secretion in lactating rats. Endocrinology. 1977 Mar;100(3):890–895. doi: 10.1210/endo-100-3-890. [DOI] [PubMed] [Google Scholar]
- Burland W. L., Gleadle R. I., Lee R. M., Rowley-Jones D., Groom G. V. Prolactin responses to cimetidine. Br J Clin Pharmacol. 1979 Jan;7(1):19–21. doi: 10.1111/j.1365-2125.1979.tb00891.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Carlson H. E., Ippoliti A. F. Cimetidine, an H2-antihistamine, stimulates prolactin secretion in man. J Clin Endocrinol Metab. 1977 Aug;45(2):367–370. doi: 10.1210/jcem-45-2-367. [DOI] [PubMed] [Google Scholar]
- Domschke W., Lux G., Domschke S. Gastric inhibitory action of H2-antagonists ranitidine and cimetidine. Lancet. 1979 Feb 10;1(8111):320–320. doi: 10.1016/s0140-6736(79)90728-1. [DOI] [PubMed] [Google Scholar]
- Lamberts S. W., Klijn J. G., Birkenhäger J. C. Prolactine. Ned Tijdschr Geneeskd. 1978 Sep 9;122(36):1327–1334. [PubMed] [Google Scholar]
- Nelis G. F., Van de Meene J. G. The effect of oral cimetidine on the basal and stimulated values of prolactin, thyroid stimulating hormone, follicle stimulating hormone and luteinizing hormone. Postgrad Med J. 1980 Jan;56(651):26–29. doi: 10.1136/pgmj.56.651.26. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Peden N. R., Saunders J. H., Wormsley K. G. Inhibition of pentagastrin-stimulated and nocturnal gastric secretion by ranitidine. A new H2-receptor antagonist. Lancet. 1979 Mar 31;1(8118):690–692. doi: 10.1016/s0140-6736(79)91146-2. [DOI] [PubMed] [Google Scholar]
- Roberts L. J., 2nd, Marney S. R., Jr, Oates J. A. Blockade of the flush associated with metastatic gastric carcinoid by combined histamine H1 and H2 receptor antagonists. Evidence for an important role of H2 receptors in human vasculature. N Engl J Med. 1979 Feb 1;300(5):236–238. doi: 10.1056/NEJM197902013000506. [DOI] [PubMed] [Google Scholar]