Abstract
Six of 14 patients receiving a sustained release papaverine preparation developed abnormal liver function tests. One patient had jaundice and another abnormal liver histology on a biopsy specimen. This is only the third report of impaired liver function following the administration of papaverine--a drug which has been used in clinical medicine for over 100 years.
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- Driemen P. M. Papaverine--hepatotoxic or not? J Am Geriatr Soc. 1973 May;21(5):202–205. doi: 10.1111/j.1532-5415.1973.tb01670.x. [DOI] [PubMed] [Google Scholar]
- Gilliss M. R. Papaverine--safety in use. J Am Geriatr Soc. 1973 May;21(5):200–201. doi: 10.1111/j.1532-5415.1973.tb01669.x. [DOI] [PubMed] [Google Scholar]
- JAYNE H. W., SCHEINBERG P., RICH M., BELLE M. S. The effect of intravenous papaverine hydrochloride on the cerebral circulation. J Clin Invest. 1952 Jan;31(1):111–114. doi: 10.1172/JCI102568. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ronnov-Jessen V., Tjernlund A. Hepatotoxicity due to treatment with papaverine. Report of four cases. N Engl J Med. 1969 Dec 11;281(24):1333–1335. doi: 10.1056/NEJM196912112812404. [DOI] [PubMed] [Google Scholar]
- Stern F. H. Management of chronic brain syndrome secondary to cerebral arteriosclerosis, with special reference to papaverine hydrochloride. J Am Geriatr Soc. 1970 Jun;18(6):507–512. doi: 10.1111/j.1532-5415.1970.tb01337.x. [DOI] [PubMed] [Google Scholar]
- WHITTIER J. R. VASORELAXANT DRUGS AND CEREBROVASCULAR DISEASE. Angiology. 1964 Feb;15:82–87. doi: 10.1177/000331976401500204. [DOI] [PubMed] [Google Scholar]
- Zimmerman H. J. Papaverine revisited as a hepatotoxin. N Engl J Med. 1969 Dec 11;281(24):1364–1365. doi: 10.1056/NEJM196912112812413. [DOI] [PubMed] [Google Scholar]