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. 1980 Apr;56(654):263–265. doi: 10.1136/pgmj.56.654.263

Sarcoidosis associated with combined immunodeficiency.

M J Crofts, M V Joyner, J C Sharp, J Costello, D Vergani
PMCID: PMC2425891  PMID: 7433328

Abstract

The association of multiple non-caseating granulomata and a positive Kviem test is normally considered to be indicative of a diagnosis of sarcoidosis. However, although depressed cell-mediated immunity is commonly described, it is extremely rare to find a humoral immune paresis. A patient is reported who had multiple granulomata, depressed cellular and humoral immunity and a positive Kveim test.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BRONSKY D., DUNN Y. O. SARCOIDOSIS WITH HYPOGAMMAGLOBULINEMIA. Am J Med Sci. 1965 Jul;250:11–18. doi: 10.1097/00000441-196507000-00003. [DOI] [PubMed] [Google Scholar]
  2. Bresnihan B., Jasin H. E. Suppressor function of peripheral blood mononuclear cells in normal individuals and in patients with systemic lupus erythematosus. J Clin Invest. 1977 Jan;59(1):106–116. doi: 10.1172/JCI108607. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Goodwin J. S., Bankhurst A. D., Messner R. P. Suppression of human T-cell mitogenesis by prostaglandin. Existence of a prostaglandin-producing suppressor cell. J Exp Med. 1977 Dec 1;146(6):1719–1734. doi: 10.1084/jem.146.6.1719. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Messerschmitt J., Faille N., Gonthier M. F., Léraillé B. Etudes sur le test de Kveim Tests positifs dans l'agammaglobulinémie Comparaison avec le TTL en présence de l'antigène de Kveim. Nouv Presse Med. 1975 Jun 7;(23):1717–1720. [PubMed] [Google Scholar]
  5. Waldmann T. A., Blaese R. M., Broder S., Krakauer R. S. Disorders of suppressor immunoregulatory cells in the pathogenesis of immunodeficiency and autoimmunity. Ann Intern Med. 1978 Feb;88(2):226–238. doi: 10.7326/0003-4819-88-2-226. [DOI] [PubMed] [Google Scholar]
  6. Zubler R. H., Lange G., Lambert P. H., Miescher P. A. Detection of immune complexes in unheated sera by modified 125I-Clq binding test. Effect of heating on the binding of Clq by immune complexes and application of the test to systemic lupus erythematosus. J Immunol. 1976 Jan;116(1):232–235. [PubMed] [Google Scholar]

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