Skip to main content
NCBI home page
Postgraduate Medical Journal logoLink to Postgraduate Medical Journal
. 1980 Jan;56(651):26–29. doi: 10.1136/pgmj.56.651.26

The effect of oral cimetidine on the basal and stimulated values of prolactin, thyroid stimulating hormone, follicle stimulating hormone and luteinizing hormone.

G F Nelis, J G Van de Meene
PMCID: PMC2425990  PMID: 6770354

Abstract

The effect of cimetidine on the basal values of PRL, TSH, FSH and LH and on the TRH/LHRH-stimulated values of these hormones was investigated in patients with peptic ulcer. No difference was found between the values before, during or after cimetidine maintenance treatment. To evaluate whether a rise in PRL occurs during the early phase of cimetidine treatment, daily estimations were made of basal PRL values during the first week of cimetidine adminstration in volunteers. No significant difference was found. It is concluded that oral cimetidine treatment has no influence on the basal and stimulated values of PRL, TSH, FSH and LH.

Full text

PDF
26

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Arakelian M. C., Libertun C. H1 and H2 histamine receptor participation in the brain control of prolactin secretion in lactating rats. Endocrinology. 1977 Mar;100(3):890–895. doi: 10.1210/endo-100-3-890. [DOI] [PubMed] [Google Scholar]
  2. Carlson H. E., Ippoliti A. F. Cimetidine, an H2-antihistamine, stimulates prolactin secretion in man. J Clin Endocrinol Metab. 1977 Aug;45(2):367–370. doi: 10.1210/jcem-45-2-367. [DOI] [PubMed] [Google Scholar]
  3. Daubresse J. C., Meunier J. C., Logny G. Plasma-prolactin and cimetidine. Lancet. 1978 Jan 14;1(8055):99–99. doi: 10.1016/s0140-6736(78)90041-7. [DOI] [PubMed] [Google Scholar]
  4. Delle Fave G. F., Tamburrano G., De Magistris L., Natoli C., Santoro M. L., Carratu R., Torsoli A. Gynaecomastia with cimetidine. Lancet. 1977 Jun 18;1(8025):1319–1319. doi: 10.1016/s0140-6736(77)91358-7. [DOI] [PubMed] [Google Scholar]
  5. Finkelstein J. W., Kapen S., Weitzman E. D., Hellman L., Boyar R. M. Twenty-four-hour plasma prolactin patterns in prepubertal and adolescent boys. J Clin Endocrinol Metab. 1978 Nov;47(5):1123–1128. doi: 10.1210/jcem-47-5-1123. [DOI] [PubMed] [Google Scholar]
  6. Funder J. W., Mercer J. E. Cimetidine, a histamine H2 receptor antagonist, occupies androgen receptors. J Clin Endocrinol Metab. 1979 Feb;48(2):189–191. doi: 10.1210/jcem-48-2-189. [DOI] [PubMed] [Google Scholar]
  7. Hall W. H. Letter: Breast changes in males on cimetidine. N Engl J Med. 1976 Oct 7;295(15):841–841. doi: 10.1056/NEJM197610072951514. [DOI] [PubMed] [Google Scholar]
  8. Jacobs L. S., Snyder P. J., Utiger R. D., Daughaday W. H. Prolactin response to thyrotropin releasing hormone in normal subjects. J Clin Endocrinol Metab. 1973 Jun;36(6):1069–1073. doi: 10.1210/jcem-36-6-1069. [DOI] [PubMed] [Google Scholar]
  9. Jacobs L. S., Snyder P. J., Wilber J. F., Utiger R. D., Daughaday W. H. Increased serum prolactin after administration of synthetic thyrotropin releasing hormone (TRH) in man. J Clin Endocrinol Metab. 1971 Dec;33(6):996–998. doi: 10.1210/jcem-33-6-996. [DOI] [PubMed] [Google Scholar]
  10. Lamberts S. W., Klijn J. G., Birkenhäger J. C. Prolactine. Ned Tijdschr Geneeskd. 1978 Sep 9;122(36):1327–1334. [PubMed] [Google Scholar]
  11. Parker D. C., Rossman L. G., Vander Laan E. F. Sleep-related, nychthermeral and briefly episodic variation in human plasma prolactin concentrations. J Clin Endocrinol Metab. 1973 Jun;36(6):1119–1124. doi: 10.1210/jcem-36-6-1119. [DOI] [PubMed] [Google Scholar]
  12. Rowley-Jones D. Cimetidine and serum-prolactin. Lancet. 1978 Sep 16;2(8090):635–635. doi: 10.1016/s0140-6736(78)92861-1. [DOI] [PubMed] [Google Scholar]
  13. Spiegel A. M., Lopatin R., Peikin S., McCarthy D. Serum-prolactin in patients receiving chronic oral cimetidine. Lancet. 1978 Apr 22;1(8069):881–881. doi: 10.1016/s0140-6736(78)90229-5. [DOI] [PubMed] [Google Scholar]
  14. Valcavi R., Bedogni G., Dall'Asta A., Dotti C., Portioli I. Single oral dose of cimetidine and prolactin. Lancet. 1978 Sep 2;2(8088):528–528. doi: 10.1016/s0140-6736(78)92253-5. [DOI] [PubMed] [Google Scholar]

Articles from Postgraduate Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES