Abstract
Nephrotic syndrome has been observed in association with different types of neoplasia. This appears to be the first report of the occurrence of the nephrotic syndrome due to membrano proliferative glomerulonephritis in association with carcinoma of the oesophagus. Although proteinuria was present before excision of the tumour, the nephrotic phase occurred subsequently. Eventually it disappeared leaving the patient with a clear urine and biochemical and histological improvement of the renal lesion (including immunofluorescent and electronmicroscopy studies). Possible mechanisms responsible for the nephrotic syndrome in this case are discussed.
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- Cantrell E. G. Nephrotic syndrome cured by removal of gastric carcinoma. Br Med J. 1969 Jun 21;2(5659):739–740. doi: 10.1136/bmj.2.5659.739. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Costanza M. E., Pinn V., Schwartz R. S., Nathanson L. Carcinoembryonic antigen-antibody complexes in a patient with colonic carcinoma and nephrotic syndrome. N Engl J Med. 1973 Sep 6;289(10):520–522. doi: 10.1056/NEJM197309062891007. [DOI] [PubMed] [Google Scholar]
- Eagen J. W. Glomerulopathies of neoplasia. Kidney Int. 1977 May;11(5):297–303. doi: 10.1038/ki.1977.47. [DOI] [PubMed] [Google Scholar]
- Higgins M. R., Randall R. E., Still W. J. Nephrotic syndrome with oat-cell carcinoma. Br Med J. 1974 Aug 17;3(5928):450–451. doi: 10.1136/bmj.3.5928.450. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lewis M. G., Loughridge L. W., Phillips T. M. Immunological studies in nephrotic syndrome associated with extrarenal malignant disease. Lancet. 1971 Jul 17;2(7716):134–135. doi: 10.1016/s0140-6736(71)92305-1. [DOI] [PubMed] [Google Scholar]
- Loughridge L. W., Lewis M. G. Nephrotic syndrome in malignant disease of non-renal origin. Lancet. 1971 Feb 6;1(7693):256–258. doi: 10.1016/s0140-6736(71)90999-8. [DOI] [PubMed] [Google Scholar]
- Lowry W. S., Munzenrider J. E., Lynch G. A. Nephrotic syndrome in Hodgkin's disease. Lancet. 1971 May 29;1(7709):1127–1127. doi: 10.1016/s0140-6736(71)91860-5. [DOI] [PubMed] [Google Scholar]
- Oldstone M. B., Theofilopoulos A. N., Gunvén P., Klein G. Immune complexes associated with neoplasia: presence of Epstein-Barr virus antigen-antibody complexes in Burkitt's lymphoma. Intervirology. 1974;4(5):292–302. doi: 10.1159/000149862. [DOI] [PubMed] [Google Scholar]
- Ozawa T., Pluss R., Lacher J., Boedecker E., Guggenheim S., Hammond W., McIntosh R. Endogenous immune complex nephropathy associated with malignancy I. Studies on the nature and immunopathogenic significance of glomerular bound antigen and antibody, isolation and characterization of tumor specific antigen and antibody and circulating immune complexes. Q J Med. 1975 Oct;44(176):523–541. [PubMed] [Google Scholar]
- Row P. G., Cameron J. S., Turner D. R., Evans D. J., White R. H., Ogg C. S., Chantler C., Brown C. B. Membranous nephropathy. Long-term follow-up and association with neoplasia. Q J Med. 1975 Apr;44(174):207–239. [PubMed] [Google Scholar]
- Sutherland J. C., Mardiney M. R., Jr Immune complex disease in the kidneys of lymphoma-leukemia patients: the presence of an oncornavirus-related antigen. J Natl Cancer Inst. 1973 Mar;50(3):633–644. doi: 10.1093/jnci/50.3.633. [DOI] [PubMed] [Google Scholar]




