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. 1982 Jan;58(675):47–51. doi: 10.1136/pgmj.58.675.47

Cerebellar cortical degeneration with ovarian carcinoma.

M M Steven, I R Mackay, P R Carnegie, P S Bhathal, R M Anderson
PMCID: PMC2426225  PMID: 6283504

Abstract

A case is described of progressive cerebellar degeneration in association with ovarian carcinoma, with nearly 4 years elapsing between the onset of neurological illness and the discovery of the carcinoma. Neither treatment with prednisolone nor surgical removal of the tumour effected any improvement, CAT scanning late in the illness showed marked cerebellar atrophy. Histology at post-mortem showed complete loss of cerebellar Purkinje cells. The cerebrospinal fluid gave weak binding to multiple neural components in a solid-phase radio-immuno-assay.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BRAIN R., HENSON R. A. Neurological syndromes associated with carcinoma: the carcinomatous neuromyopathies. Lancet. 1958 Nov 8;2(7054):971–975. doi: 10.1016/s0140-6736(58)90471-9. [DOI] [PubMed] [Google Scholar]
  2. Baker H. I., Jr, Houser O. W. Computed tomography in the diagnosis of posterior fossa lesions. Radiol Clin North Am. 1976 Apr;14(1):129–147. [PubMed] [Google Scholar]
  3. Brain L., Wilkinson M. Subacute cerebellar degeneration associated with neoplasms. Brain. 1965 Sep;88(3):465–478. doi: 10.1093/brain/88.3.465. [DOI] [PubMed] [Google Scholar]
  4. Coates A. S., Carnegie P. R. Immunological cross-reactivity between basic proteins of myelin and cancer. I. Lymphocyte transformation studies in immunized guinea-pigs. Clin Exp Immunol. 1975 Oct;22(1):16–21. [PMC free article] [PubMed] [Google Scholar]
  5. Croft P. B., Wilkinson M. The incidence of carcinomatous neuromyopathy in patients with various types of carcinoma. Brain. 1965 Sep;88(3):427–434. doi: 10.1093/brain/88.3.427. [DOI] [PubMed] [Google Scholar]
  6. Croft P. Neuromuscular syndromes associated with malignant disease. Br J Hosp Med. 1977 Apr;17(4):356, 360-2. [PubMed] [Google Scholar]
  7. Flavell D. J., Goepel J., Wilson A. P., Potter C. W. Immunological cross-reactivity between acid extracts of myelin, liver and neoplastic tissues: studies in immunized guinea-pigs. Br J Cancer. 1979 Sep;40(3):424–436. doi: 10.1038/bjc.1979.198. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Henson R. A. Non-metastatic neurological minifestations of malignant disease. Mod Trends Neurol. 1970;5(0):209–225. [PubMed] [Google Scholar]
  9. Joynt R. J. Neurogenic paraneoplastic syndromes. The brain's uneasy peace with tumors. Ann N Y Acad Sci. 1974;230:342–347. doi: 10.1111/j.1749-6632.1974.tb14467.x. [DOI] [PubMed] [Google Scholar]
  10. Marier R., Jansen M., Andriole V. T. A new method for measuring antibody using radiolabeled protein A1 in a solid-phase radioimmunoassay. J Immunol Methods. 1979;28(1-2):41–49. doi: 10.1016/0022-1759(79)90326-0. [DOI] [PubMed] [Google Scholar]
  11. Paone J. F., Jeyasingham K. Remission of cerebellar dysfunction after pneumonectomy for bronchogenic carcinoma. N Engl J Med. 1980 Jan 17;302(3):156–156. doi: 10.1056/NEJM198001173020305. [DOI] [PubMed] [Google Scholar]
  12. SMITH J. K., GONDA V. E., MALAMUD N. Unusual form of cerebellar ataxia; combined dentato-rubral and pallido-Luysian degeneration. Neurology. 1958 Mar;8(3):205–209. doi: 10.1212/wnl.8.3.205. [DOI] [PubMed] [Google Scholar]
  13. Vick N., Schulman S., Dau P. Carcinomatous cerebellar degeneration, encephalomyelitis, and sensory neuropathy (radiculitis). Report of a case incorporating both purely degenerative and intense inflammatory changes, with special prominence of the latter in the putamen. Neurology. 1969 May;19(5):425–441. doi: 10.1212/wnl.19.5.425. [DOI] [PubMed] [Google Scholar]
  14. WILKINSON P. C. SEROLOGICAL FINDINGS IN CARCINOMATOUS NEUROMYOPATHY. Lancet. 1964 Jun 13;1(7346):1301–1303. doi: 10.1016/s0140-6736(64)91694-0. [DOI] [PubMed] [Google Scholar]
  15. Wilkinson P. C., Zeromski J. Immunofluorescent detection of antibodies against neurones in sensory carcinomatous neuropathy. Brain. 1965 Sep;88(3):529–583. doi: 10.1093/brain/88.3.529. [DOI] [PubMed] [Google Scholar]
  16. Woodhouse M. A., Dayan A. D., Burston J., Caldwell I., Adams J. H., Melcher D., Urich H. Progressive multifocal leukoencephalopathy: electron microscope study of four cases. Brain. 1967 Dec;90(4):863–870. doi: 10.1093/brain/90.4.863. [DOI] [PubMed] [Google Scholar]
  17. Zeromski J., Wilkinson P. C. Immunological aspects of carcinomatous neuropathy: some observations on the nature of the neuronal antigen. Pathol Eur. 1966;1(1):298–310. [PubMed] [Google Scholar]

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