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. 1982 Feb;58(676):77–79. doi: 10.1136/pgmj.58.676.77

Penicillin sensitivities of gonoccocci, in 1977-80 from a peripheral health district, and their clinical correlation

M Rahman
PMCID: PMC2426295  PMID: 6808472

Abstract

Penicillin sensitivities of gonococci isolated from a peripheral health district were observed during 1977-80 by determining the minimum inhibitory concentrations (MIC) of penicillin. During the same period, outcome of penicillin treatment in patients with gonorrhoea was also observed and recorded. Penicillin resistance, as defined, was found in 19·3% strains in these years, but there were year-to-year variations. None of the strains was a penicillinase producer. Association of higher MICs of penicillin with therapeutic failures was not observed in this study until the MICs were greater than 1·0 mg/l. The findings are discussed together with reviews from other published works.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Holmes K. K., Karney W. W., Harnisch J. P., Wiesner P. J., Turck M., Pedersen A. H. Single-dose aqueous procaine penicillin G therapy for gonorrhea: use of probenecid and cause of treatment failure. J Infect Dis. 1973 Apr;127(4):455–460. doi: 10.1093/infdis/127.4.455. [DOI] [PubMed] [Google Scholar]
  2. Jaffe H. W., Schroeter A. L., Reynolds G. H., Zaidi A. A., Martin J. E., Jr, Thayer J. D. Pharmacokinetic determinants of penicillin cure of gonococcal urethritis. Antimicrob Agents Chemother. 1979 Apr;15(4):587–591. doi: 10.1128/aac.15.4.587. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Meheus A., Piot P., Pattyn S., van Dyck E., van den Berghe D. Activity in vitro of ten antimicrobial agents against Neisseria gonorrhoeae. A study of the correlation between the sensitivities. Br J Vener Dis. 1976 Oct;52(5):329–332. doi: 10.1136/sti.52.5.329. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Nayyar K. C., Michel M. F., Stolz E. Antibiotic sensitivities of gonococci isolated in Rotterdam and results of treatment with cefuroxime. Br J Vener Dis. 1980 Aug;56(4):249–251. doi: 10.1136/sti.56.4.249. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Percival A., Rowlands J., Corkill J. E., Alergant C. D., Arya O. P., Rees E., Annels E. H. Penicillinase-producing Gonococci in Liverpool. Lancet. 1976 Dec 25;2(8000):1379–1382. doi: 10.1016/s0140-6736(76)91919-x. [DOI] [PubMed] [Google Scholar]
  6. Phillips I. Beta-lactamase-producing, penicillin-resistant gonococcus. Lancet. 1976 Sep 25;2(7987):656–657. doi: 10.1016/s0140-6736(76)92466-1. [DOI] [PubMed] [Google Scholar]
  7. Rahman M. Antibiotic resistance in Streptococcus pneumoniae and Haemophilus influenzae. Br Med J. 1978 Aug 19;2(6136):569–569. doi: 10.1136/bmj.2.6136.569. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Seth A. D., Johnston N. A. Penicillin-resistant gonococci. Lancet. 1980 Sep 6;2(8193):531–531. doi: 10.1016/s0140-6736(80)91852-8. [DOI] [PubMed] [Google Scholar]
  9. Seth A. D., Kolator B., Wilkinson A. E. Sensitivity of Neisseria gonorrhoeae to antibiotics in London (1976-78). Br J Vener Dis. 1979 Oct;55(5):325–328. doi: 10.1136/sti.55.5.325. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Shtibel R. Non-beta-lactamase producing Neisseria gonorrhorea highly resistant to penicillin. Lancet. 1980 Jul 5;2(8184):39–39. doi: 10.1016/s0140-6736(80)92917-7. [DOI] [PubMed] [Google Scholar]

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