Abstract
A woman aged 23 years is described who had watery diarrhoea and colicky abdominal pain with normal results on sigmoidoscopy and barium enema. Rectal biopsy showed a thick layer of collagen in the lamina propria below the free epithelial surface. This lesion extended throughout the length of the descending colon. The only change revealed by electron microscopy was an increase in the thickness of the sub-epithelial collagen layer which is normally present in the colon. The maturation of the fibroblasts was normal. The lesion in this patient may be considered as a small change from the normal situation. This lesion is typical of ‘collagenous colitis’ of which only three other cases have as yet been published.
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- Bogomoletz W. V., Adnet J. J., Birembaut P., Feydy P., Dupont P. Collagenous colitis: an unrecognised entity. Gut. 1980 Feb;21(2):164–168. doi: 10.1136/gut.21.2.164. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Eidelman S., Lagunoff D. The morphology of the normal human rectal biopsy. Hum Pathol. 1972 Sep;3(3):389–401. doi: 10.1016/s0046-8177(72)80039-x. [DOI] [PubMed] [Google Scholar]
- Kaye G. I., Lane N., Pascal R. R. Colonic pericryptal fibroblast sheath: replication, migration, and cytodifferentiation of a mesenchymal cell system in adult tissue. II. Fine structural aspects of normal rabbit and human colon. Gastroenterology. 1968 May;54(5):852–865. [PubMed] [Google Scholar]
- Nielsen V. T., Vetner M., Harsløf E. Collagenous colitis. Histopathology. 1980 Jan;4(1):83–86. doi: 10.1111/j.1365-2559.1980.tb02900.x. [DOI] [PubMed] [Google Scholar]